Wolfram Goessling

Publications

• Quantitative Intravital Imaging in Zebrafish Reveals Dynamics of Physiological-stress-induced Mitophagy
  Journal of Cell Science. Feb, 2021  |   Pubmed ID: 33536245
• Learning During and From a Crisis: The Student-Led Development of a COVID-19 Curriculum
  Academic Medicine : Journal of the Association of American Medical Colleges. 03, 2021  |   Pubmed ID: 32941252
• Functional Compensation Precedes Recovery of Tissue Mass Following Acute Liver Injury
  Nature Communications. 11, 2020  |   Pubmed ID: 33214549
• The Cationic Amino Acid Exporter Slc7a7 is Induced and Vital in Zebrafish Tissue Macrophages with Sustained Efferocytic Activity
  Journal of Cell Science. Oct, 2020  |   Pubmed ID: 32973110
• Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production
  Developmental Cell. 10, 2020  |   Pubmed ID: 32810442
• Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity
  IScience. Aug, 2020  |   Pubmed ID: 32712466
• Hepatobiliary Differentiation: Principles from Embryonic Liver Development
  Seminars in Liver Disease. Nov, 2020  |   Pubmed ID: 32526786
• Fetal Alcohol Spectrum Disorder Predisposes to Metabolic Abnormalities in Adulthood
  The Journal of Clinical Investigation. 05, 2020  |   Pubmed ID: 32202514
• Synthetic CRISPR/Cas9 Reagents Facilitate Genome Editing and Homology Directed Repair
  Nucleic Acids Research. 04, 2020  |   Pubmed ID: 32064511
• Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development
  Hepatology (Baltimore, Md.). Nov, 2020  |   Pubmed ID: 32060934
• YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow
  Developmental Cell. 02, 2020  |   Pubmed ID: 32032546
• A Phase 2 Clinical Trial of the Heat Shock Protein 90 (HSP 90) Inhibitor Ganetespib in Patients with Refractory Advanced Esophagogastric Cancer
  Investigational New Drugs. 10, 2020  |   Pubmed ID: 31898183
• A Quantitative Single-cell Assay for Retrograde Membrane Traffic Enables Rapid Detection of Defects in Cellular Organization
  Molecular Biology of the Cell. 03, 2020  |   Pubmed ID: 31774722
• Macrophages in Zebrafish Models of Liver Diseases
  Frontiers in Immunology. 2019  |   Pubmed ID: 31867007
• Mutations in RABL3 Alter KRAS Prenylation and Are Associated with Hereditary Pancreatic Cancer
  Nature Genetics. 09, 2019  |   Pubmed ID: 31406347
• Tfap2a is a Novel Gatekeeper of Nephron Differentiation During Kidney Development
  Development (Cambridge, England). 07, 2019  |   Pubmed ID: 31160420
• There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma
  Cellular and Molecular Gastroenterology and Hepatology. 2019  |   Pubmed ID: 31108233
• Position Is Destiny: Metabolism and Cell Identity
  Cell Metabolism. 05, 2019  |   Pubmed ID: 31067445
• Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and MTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes
  Gastroenterology. 05, 2019  |   Pubmed ID: 30641053
• Yap Regulates Glucose Utilization and Sustains Nucleotide Synthesis to Enable Organ Growth
  The EMBO Journal. 11, 2018  |   Pubmed ID: 30348863
• An Integrated Clinical Program and Crowdsourcing Strategy for Genomic Sequencing and Mendelian Disease Gene Discovery
  NPJ Genomic Medicine. 2018  |   Pubmed ID: 30131872
• The Zebrafish Kidney Mutant Zeppelin Reveals That Brca2/fancd1 is Essential for Pronephros Development
  Developmental Biology. Aug, 2017  |   Pubmed ID: 28579318
• WNTing No RASt for Hepatocellular Carcinoma
  Hepatology (Baltimore, Md.). 05, 2017  |   Pubmed ID: 28295459
• and Loci Identified Through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
  Journal of the American Society of Nephrology : JASN. Mar, 2017  |   Pubmed ID: 27920155
• Multiethnic Genome-wide Meta-analysis of Ectopic Fat Depots Identifies Loci Associated with Adipocyte Development and Differentiation
  Nature Genetics. 01, 2017  |   Pubmed ID: 27918534
• Haematopoietic Stem Cells Show Their True Colours
  Nature Cell Biology. Dec, 2016  |   Pubmed ID: 28008181
• Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production
  Cell Reports. 10, 2016  |   Pubmed ID: 27705794
• Selenoprotein H is an Essential Regulator of Redox Homeostasis That Cooperates with P53 in Development and Tumorigenesis
  Proceedings of the National Academy of Sciences of the United States of America. 09, 2016  |   Pubmed ID: 27588899
• Iterative Use of Nuclear Receptor Nr5a2 Regulates Multiple Stages of Liver and Pancreas Development
  Developmental Biology. 10, 2016  |   Pubmed ID: 27474396
• Yap Reprograms Glutamine Metabolism to Increase Nucleotide Biosynthesis and Enable Liver Growth
  Nature Cell Biology. 08, 2016  |   Pubmed ID: 27428308
• The Central Nervous System Regulates Embryonic HSPC Production Via Stress-Responsive Glucocorticoid Receptor Signaling
  Cell Stem Cell. 09, 2016  |   Pubmed ID: 27424782
• Nature and Nurture: Environmental Toxins and Biliary Atresia
  Hepatology (Baltimore, Md.). 09, 2016  |   Pubmed ID: 27349921
• Mitochondrial Dysfunction Remodels One-carbon Metabolism in Human Cells
  ELife. 06, 2016  |   Pubmed ID: 27307216
• Baiting for Cancer: Using the Zebrafish As a Model in Liver and Pancreatic Cancer
  Advances in Experimental Medicine and Biology. 2016  |   Pubmed ID: 27165363
• EnaBILEing Growth in the Fetal Liver
  Cell Stem Cell. Apr, 2016  |   Pubmed ID: 27058931
• Hypoxia As a Therapy for Mitochondrial Disease
  Science (New York, N.Y.). Apr, 2016  |   Pubmed ID: 26917594
• Cannabinoid Receptor Signaling Regulates Liver Development and Metabolism
  Development (Cambridge, England). Feb, 2016  |   Pubmed ID: 26884397
• Genetic Associations at 53 Loci Highlight Cell Types and Biological Pathways Relevant for Kidney Function
  Nature Communications. 2016  |   Pubmed ID: 26831199
• Ferritinophagy Via NCOA4 is Required for Erythropoiesis and is Regulated by Iron Dependent HERC2-mediated Proteolysis
  ELife. Oct, 2015  |   Pubmed ID: 26436293
• Systematic Proteomics of the VCP-UBXD Adaptor Network Identifies a Role for UBXN10 in Regulating Ciliogenesis
  Nature Cell Biology. Oct, 2015  |   Pubmed ID: 26389662
• Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation
  Stem Cell Reports. Oct, 2015  |   Pubmed ID: 26365513
• Zebrafish: an Important Tool for Liver Disease Research
  Gastroenterology. Nov, 2015  |   Pubmed ID: 26319012
• Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development Via Prostaglandin E2 and P-Selectin Activity
  Stem Cells (Dayton, Ohio). Aug, 2015  |   Pubmed ID: 25931248
• The Lure of Zebrafish in Liver Research: Regulation of Hepatic Growth in Development and Regeneration
  Current Opinion in Genetics & Development. Jun, 2015  |   Pubmed ID: 25863341
• ANKS6 is the Critical Activator of NEK8 Kinase in Embryonic Situs Determination and Organ Patterning
  Nature Communications. 2015  |   Pubmed ID: 25599650
• Genome-wide Association Study of Kidney Function Decline in Individuals of European Descent
  Kidney International. May, 2015  |   Pubmed ID: 25493955
• Repairing Quite Swimmingly: Advances in Regenerative Medicine Using Zebrafish
  Disease Models & Mechanisms. Jul, 2014  |   Pubmed ID: 24973747
• Estrogen Defines the Dorsal-ventral Limit of VEGF Regulation to Specify the Location of the Hemogenic Endothelial Niche
  Developmental Cell. May, 2014  |   Pubmed ID: 24871948
• Regenerative Biology: Take the Brakes off for Liver Repair
  Nature. Feb, 2014  |   Pubmed ID: 24553235
• Prostaglandin E2 Regulates Liver Versus Pancreas Cell-fate Decisions and Endodermal Outgrowth
  Developmental Cell. Feb, 2014  |   Pubmed ID: 24530296
• S-nitrosothiol Signaling Regulates Liver Development and Improves Outcome Following Toxic Liver Injury
  Cell Reports. Jan, 2014  |   Pubmed ID: 24388745
• Rapid Identification of Kidney Cyst Mutations by Whole Exome Sequencing in Zebrafish
  Development (Cambridge, England). Nov, 2013  |   Pubmed ID: 24130329
• Functional Validation of GWAS Gene Candidates for Abnormal Liver Function During Zebrafish Liver Development
  Disease Models & Mechanisms. Sep, 2013  |   Pubmed ID: 23813869
• Identification of Small Molecules for Human Hepatocyte Expansion and IPS Differentiation
  Nature Chemical Biology. Jun, 2013  |   Pubmed ID: 23728495
• Glucose Metabolism Impacts the Spatiotemporal Onset and Magnitude of HSC Induction in Vivo
  Blood. Mar, 2013  |   Pubmed ID: 23341543
• β-Catenin-driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
  Cell. Dec, 2012  |   Pubmed ID: 23245941
• Rargb Regulates Organ Laterality in a Zebrafish Model of Right Atrial Isomerism
  Developmental Biology. Dec, 2012  |   Pubmed ID: 22982668
• SCF(β-TRCP) Suppresses Angiogenesis and Thyroid Cancer Cell Migration by Promoting Ubiquitination and Destruction of VEGF Receptor 2
  The Journal of Experimental Medicine. Jul, 2012  |   Pubmed ID: 22711876
• Mutation Mapping and Identification by Whole-genome Sequencing
  Genome Research. Aug, 2012  |   Pubmed ID: 22555591
• Genome-wide Association and Functional Follow-up Reveals New Loci for Kidney Function
  PLoS Genetics. 2012  |   Pubmed ID: 22479191
• Genome-wide Association Study Identifies Loci Influencing Concentrations of Liver Enzymes in Plasma
  Nature Genetics. Nov, 2011  |   Pubmed ID: 22001757
• Hematopoietic Stem Cell Development: Using the Zebrafish to Identify the Signaling Networks and Physical Forces Regulating Hematopoiesis
  Methods in Cell Biology. 2011  |   Pubmed ID: 21951528
• Genetic Association for Renal Traits Among Participants of African Ancestry Reveals New Loci for Renal Function
  PLoS Genetics. Sep, 2011  |   Pubmed ID: 21931561
• Deficiency of the Cytoskeletal Protein SPECC1L Leads to Oblique Facial Clefting
  American Journal of Human Genetics. Jul, 2011  |   Pubmed ID: 21703590
• Endoderm Specification, Liver Development, and Regeneration
  Methods in Cell Biology. 2011  |   Pubmed ID: 21550446
• Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-term Safety in Preclinical Nonhuman Primate Transplant Models
  Cell Stem Cell. Apr, 2011  |   Pubmed ID: 21474107
• The Wnt/beta-catenin Pathway is Required for the Development of Leukemia Stem Cells in AML
  Science (New York, N.Y.). Mar, 2010  |   Pubmed ID: 20339075
• Previews. NOTCHing an Arrow at Cord Blood: Translating Stem Cell Knowledge into Clinical Practice
  Cell Stem Cell. Mar, 2010  |   Pubmed ID: 20207217
• PTGER2 Overexpression in Colorectal Cancer is Associated with Microsatellite Instability, Independent of CpG Island Methylator Phenotype
  Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Mar, 2010  |   Pubmed ID: 20200425
• Hematopoietic Stem Cell Development is Dependent on Blood Flow
  Cell. May, 2009  |   Pubmed ID: 19450519
• Topoisomerase II Alpha is Required for Embryonic Development and Liver Regeneration in Zebrafish
  Molecular and Cellular Biology. Jul, 2009  |   Pubmed ID: 19380487
• Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration
  Cell. Mar, 2009  |   Pubmed ID: 19303855
• Aminotransferase Levels and 20-year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease
  Gastroenterology. Dec, 2008  |   Pubmed ID: 19010326
• APC Mutant Zebrafish Uncover a Changing Temporal Requirement for Wnt Signaling in Liver Development
  Developmental Biology. Aug, 2008  |   Pubmed ID: 18585699
• Transparent Adult Zebrafish As a Tool for in Vivo Transplantation Analysis
  Cell Stem Cell. Feb, 2008  |   Pubmed ID: 18371439
• Prostaglandin E2 Regulates Vertebrate Haematopoietic Stem Cell Homeostasis
  Nature. Jun, 2007  |   Pubmed ID: 17581586
• Ultrasound Biomicroscopy Permits in Vivo Characterization of Zebrafish Liver Tumors
  Nature Methods. Jul, 2007  |   Pubmed ID: 17572681
• New Waves of Discovery: Modeling Cancer in Zebrafish
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2007  |   Pubmed ID: 17557959
• Increased Liver Chemistry in an Asymptomatic Patient
  Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Sep, 2005  |   Pubmed ID: 16234021
• Merkel Cell Carcinoma
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2002  |   Pubmed ID: 11786590