Xander H.T. Wehrens Department of Molecular Physiology and Biophysics Baylor College of Medicine (BCM) Biography Publications Institution JoVE Articles Xander H.T. Wehrens has not added a biography. If you are Xander H.T. Wehrens and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice Circulation Research. Feb, 2012 | Pubmed ID: 22158709 Pathogenesis of Lethal Cardiac Arrhythmias in Mecp2 Mutant Mice: Implication for Therapy in Rett Syndrome Science Translational Medicine. Dec, 2011 | Pubmed ID: 22174313 Enhanced Impact of SCN5A Mutation Associated with Long QT Syndrome in Fetal Splice Isoform Heart Rhythm : the Official Journal of the Heart Rhythm Society. Nov, 2011 | Pubmed ID: 22138134 Overexpression of CAMP-response Element Modulator Causes Abnormal Growth and Development of the Atrial Myocardium Resulting in a Substrate for Sustained Atrial Fibrillation in Mice International Journal of Cardiology. Nov, 2011 | Pubmed ID: 22093963 Defects in Ankyrin-based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation Circulation. Sep, 2011 | Pubmed ID: 21859974 Targeting Ryanodine Receptors for Anti-arrhythmic Therapy Acta Pharmacologica Sinica. Jun, 2011 | Pubmed ID: 21642946 Association of Systolic Blood Pressure with Mortality in Patients with Heart Failure with Reduced Ejection Fraction: a Complex Relationship American Heart Journal. Mar, 2011 | Pubmed ID: 21392613 Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice Circulation. Mar, 2011 | Pubmed ID: 21339484 Junctophilin-2 Expression Silencing Causes Cardiocyte Hypertrophy and Abnormal Intracellular Calcium-handling Circulation. Heart Failure. Mar, 2011 | Pubmed ID: 21216834 The Ryanodine Receptor Channel As a Molecular Motif in Atrial Fibrillation: Pathophysiological and Therapeutic Implications Cardiovascular Research. Mar, 2011 | Pubmed ID: 20943673 CaMKII Regulation of the Cardiac Ryanodine Receptor and Sarcoplasmic Reticulum Calcium Release Heart Rhythm : the Official Journal of the Heart Rhythm Society. Feb, 2011 | Pubmed ID: 20887810 Digoxin Treatment in Heart Failure - Unveiling Risk by Cluster Analysis of DIG Data International Journal of Cardiology. Aug, 2011 | Pubmed ID: 20471706 Ryanodine Receptor Phosphorylation by Calcium/calmodulin-dependent Protein Kinase II Promotes Life-threatening Ventricular Arrhythmias in Mice with Heart Failure Circulation. Dec, 2010 | Pubmed ID: 21098440 Emerging Role of Junctophilin-2 As a Regulator of Calcium Handling in the Heart Acta Pharmacologica Sinica. Sep, 2010 | Pubmed ID: 20694023 Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation Trends in Cardiovascular Medicine. Jan, 2010 | Pubmed ID: 20685575 Genetic Inhibition of PKA Phosphorylation of RyR2 Prevents Dystrophic Cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20615971 Pitx2 Prevents Susceptibility to Atrial Arrhythmias by Inhibiting Left-sided Pacemaker Specification Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20457925 Accelerated Development of Pressure Overload-induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model Hypertension. Apr, 2010 | Pubmed ID: 20157052 Stress Synchronizes Calcium Release and Promotes SR Calcium Leak The Journal of Physiology. Feb, 2010 | Pubmed ID: 20123791 Heart-specific Overexpression of CUGBP1 Reproduces Functional and Molecular Abnormalities of Myotonic Dystrophy Type 1 Human Molecular Genetics. Mar, 2010 | Pubmed ID: 20051426 Sudden Infant Death Syndrome in Mice with an Inherited Mutation in RyR2 Circulation. Arrhythmia and Electrophysiology. Dec, 2009 | Pubmed ID: 20009080 PKC Inhibition Ameliorates the Cardiac Phenotype in a Mouse Model of Myotonic Dystrophy Type 1 The Journal of Clinical Investigation. Dec, 2009 | Pubmed ID: 19907076 Animal Models of Arrhythmogenic Cardiomyopathy Disease Models & Mechanisms. Nov-Dec, 2009 | Pubmed ID: 19892887 Calmodulin Kinase II-mediated Sarcoplasmic Reticulum Ca2+ Leak Promotes Atrial Fibrillation in Mice The Journal of Clinical Investigation. Jul, 2009 | Pubmed ID: 19603549 Molecular Evolution of the Junctophilin Gene Family Physiological Genomics. May, 2009 | Pubmed ID: 19318539 Calmodulin Kinase II is Required for Fight or Flight Sinoatrial Node Physiology Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19276108 Exercise Training During Diabetes Attenuates Cardiac Ryanodine Receptor Dysregulation Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2009 | Pubmed ID: 19131475 Alternative Splicing: a Key Mechanism for Ankyrin-B Functional Diversity? Journal of Molecular and Cellular Cardiology. Dec, 2008 | Pubmed ID: 18838078 Intracellular Calcium Leak Due to FKBP12.6 Deficiency in Mice Facilitates the Inducibility of Atrial Fibrillation Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jul, 2008 | Pubmed ID: 18598963 Mechanisms of Human Arrhythmia Syndromes: Abnormal Cardiac Macromolecular Interactions Physiology (Bethesda, Md.). Oct, 2007 | Pubmed ID: 17928548 Mutation-specific Effects of Lidocaine in Brugada Syndrome International Journal of Cardiology. Oct, 2007 | Pubmed ID: 17761312 Phosphorylation of RyR2 and Shortening of RyR2 Cluster Spacing in Spontaneously Hypertensive Rat with Heart Failure American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2007 | Pubmed ID: 17630346 Ryanodine Receptors As Pharmacological Targets for Heart Disease Acta Pharmacologica Sinica. Jul, 2007 | Pubmed ID: 17588328 The Molecular Basis of Catecholaminergic Polymorphic Ventricular Tachycardia: What Are the Different Hypotheses Regarding Mechanisms? Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jun, 2007 | Pubmed ID: 17556207 Mutations in JPH2-encoded Junctophilin-2 Associated with Hypertrophic Cardiomyopathy in Humans Journal of Molecular and Cellular Cardiology. Jun, 2007 | Pubmed ID: 17509612 Leaky Ryanodine Receptors Cause Delayed Afterdepolarizations and Ventricular Arrhythmias European Heart Journal. May, 2007 | Pubmed ID: 17459904 Subcellular Targeting of Phosphatases: a Novel Function of Ankyrins American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007 | Pubmed ID: 17449551 Mice with the R176Q Cardiac Ryanodine Receptor Mutation Exhibit Catecholamine-induced Ventricular Tachycardia and Cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16873551 Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16672364 Analysis of Calstabin2 (FKBP12.6)-ryanodine Receptor Interactions: Rescue of Heart Failure by Calstabin2 in Mice Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16481613 Ryanodine Receptor/calcium Release Channel PKA Phosphorylation: a Critical Mediator of Heart Failure Progression Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16407108 Phosphodiesterase 4D Deficiency in the Ryanodine-receptor Complex Promotes Heart Failure and Arrhythmias Cell. Oct, 2005 | Pubmed ID: 16213210 Ryanodine Receptor-targeted Anti-arrhythmic Therapy Annals of the New York Academy of Sciences. Jun, 2005 | Pubmed ID: 16093511 Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca2+ Leak: a Novel Therapeutic Target in Heart Failure Circulation. Jun, 2005 | Pubmed ID: 15983258 Enhancing Calstabin Binding to Ryanodine Receptors Improves Cardiac and Skeletal Muscle Function in Heart Failure Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 15972811 Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation Circulation. Apr, 2005 | Pubmed ID: 15851612 Intracellular Calcium Release and Cardiac Disease Annual Review of Physiology. 2005 | Pubmed ID: 15709953 Sudden Unexplained Death Caused by Cardiac Ryanodine Receptor (RyR2) Mutations Mayo Clinic Proceedings. Mayo Clinic. Nov, 2004 | Pubmed ID: 15544013 Calstabin Deficiency, Ryanodine Receptors, and Sudden Cardiac Death Biochemical and Biophysical Research Communications. Oct, 2004 | Pubmed ID: 15336974 Novel Therapeutic Approaches for Heart Failure by Normalizing Calcium Cycling Nature Reviews. Drug Discovery. Jul, 2004 | Pubmed ID: 15232578 Cardiac Ryanodine Receptor Function and Regulation in Heart Disease Annals of the New York Academy of Sciences. May, 2004 | Pubmed ID: 15201156 Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated with Calcium Release Channel (ryanodine Receptor) Leak Circulation. Jun, 2004 | Pubmed ID: 15197150 Cardiac Rupture Complicating Myocardial Infarction International Journal of Cardiology. Jun, 2004 | Pubmed ID: 15193834 Molecular Determinants of Altered Contractility in Heart Failure Annals of Medicine. 2004 | Pubmed ID: 15176427 Fetal Cardiovascular Response to Large Placental Chorioangiomas Journal of Perinatal Medicine. 2004 | Pubmed ID: 15085884 Protection from Cardiac Arrhythmia Through Ryanodine Receptor-stabilizing Protein Calstabin2 Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15073377 Ca2+/calmodulin-dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor Circulation Research. Apr, 2004 | Pubmed ID: 15016728 Altered Function and Regulation of Cardiac Ryanodine Receptors in Cardiac Disease Trends in Biochemical Sciences. Dec, 2003 | Pubmed ID: 14659699 FKBP12.6 Deficiency and Defective Calcium Release Channel (ryanodine Receptor) Function Linked to Exercise-induced Sudden Cardiac Death Cell. Jun, 2003 | Pubmed ID: 12837242 Beta-blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure Circulation. May, 2003 | Pubmed ID: 12743001 Non-equilibrium Gating in Cardiac Na+ Channels: an Original Mechanism of Arrhythmia Circulation. May, 2003 | Pubmed ID: 12695286 A Novel Mutation L619F in the Cardiac Na+ Channel SCN5A Associated with Long-QT Syndrome (LQT3): a Role for the I-II Linker in Inactivation Gating Human Mutation. May, 2003 | Pubmed ID: 12673799 K+ Channel Structure-activity Relationships and Mechanisms of Drug-induced QT Prolongation Annual Review of Pharmacology and Toxicology. 2003 | Pubmed ID: 12540747 Novel Insights in the Congenital Long QT Syndrome Annals of Internal Medicine. Dec, 2002 | Pubmed ID: 12484714 Angiogenesis-independent Cardioprotection in FGF-1 Transgenic Mice Cardiovascular Research. Sep, 2002 | Pubmed ID: 12176126 Especially Polymorphonuclear Leukocytes, but Also Monomorphonuclear Leukocytes, Roll Spontaneously in Venules of Intact Rat Skin: Involvement of E-selectin The Journal of Investigative Dermatology. Feb, 2002 | Pubmed ID: 11841551 Transthoracic Echocardiography in Mice Jonathan L. Respress1, Xander H.T. Wehrens1,2 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), 2The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM) JoVE 1738 Medicine Transverse Aortic Constriction in Mice Angela C. deAlmeida1, Ralph J. van Oort1, Xander H.T. Wehrens1,2 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), 2The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM) JoVE 1729 Biology
Transthoracic Echocardiography in Mice Jonathan L. Respress1, Xander H.T. Wehrens1,2 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), 2The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM) JoVE 1738 Medicine
Transverse Aortic Constriction in Mice Angela C. deAlmeida1, Ralph J. van Oort1, Xander H.T. Wehrens1,2 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM), 2The Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine (BCM) JoVE 1729 Biology
