Xiang Xue Department of Biochemistry and Molecular Biology, School of Medicine University of New Mexico Biography Publications Institution JoVE Articles Xiang XueAssistant Professor Dr. Xue’s lab is focused on studying molecular mechanisms for inflammatory bowel disease (IBD) and colorectal cancer (CRC). He utilizes cell line and enteroid cultures, mouse models, patient tissues and a wide array of molecular and biochemical methodologies. Several ongoing projects in the lab include:Why are micronutrients essential for cancer cell growth?How does mitochondrial metabolism regulate the progress of cancer?Whether stress activated pathways play a role in cancer cell metabolism?What role does hypoxia signaling have in intestinal inflammation and colorectal cancer?What is the critical link between nutrient homeostasis, inflammation and cancer? Publications Polydatin Protects Cardiac Function Against Burn Injury by Inhibiting Sarcoplasmic Reticulum Ca(2+) Leak by Reducing Oxidative Modification of Ryanodine Receptors Free Radical Biology & Medicine. Jul, 2013 | Pubmed ID: 23499836 Membrane Association of Wuhan Nodavirus Protein A is Required for Its Ability to Accumulate Genomic RNA1 Template Virology. May, 2013 | Pubmed ID: 23490047 Evaluation of Risk Factors for Venous Thromboembolism in Chinese Women with Epithelial Ovarian Cancer International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. Jan, 2013 | Pubmed ID: 23196757 High Frequency of Putative Ovarian Cancer Stem Cells With CD44/CK19 Coexpression Is Associated With Decreased Progression-Free Intervals In Patients With Recurrent Epithelial Ovarian Cancer Reproductive Sciences (Thousand Oaks, Calif.). May, 2013 | Pubmed ID: 23171677 Hypoxia-inducible Factor-2α is Essential in Activating the COX2/mPGES-1/PGE2 Signaling Axis in Colon Cancer Carcinogenesis. Jan, 2013 | Pubmed ID: 23042097 [Analysis of Death Characteristics and Its Potential Mechanisms in Rats with Endotoxin- Induced Cardiomyopathy] Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue. Dec, 2012 | Pubmed ID: 23168204 [Effects of Abdominal Compartment Syndrome on Circulation and Respiratory Function in Rabbits] Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. Sep, 2012 | Pubmed ID: 22985571 The Hypoxia-inducible Factor-C/EBPα Axis Controls Ethanol-mediated Hepcidin Repression Molecular and Cellular Biology. Oct, 2012 | Pubmed ID: 22869521 [Effects of Somatostatin in a Rabbit Model of Abdominal Compartment Syndrome Induced by Prolonged Intra-abdominal Hypertension] Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. Mar, 2012 | Pubmed ID: 22445990 Targeting of Dicer-2 and RNA by a Viral RNA Silencing Suppressor in Drosophila Cells Journal of Virology. May, 2012 | Pubmed ID: 22438534 Hypoxia-inducible Factor-2α Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis Cancer Research. May, 2012 | Pubmed ID: 22419665 Structural Basis and Kinetics of Force-induced Conformational Changes of an αA Domain-containing Integrin PloS One. Month, 2011 | Pubmed ID: 22140490 Critical Role of Organic Anion Transporters 1 and 3 in Kidney Accumulation and Toxicity of Aristolochic Acid I Molecular Pharmaceutics. Dec, 2011 | Pubmed ID: 21980933 Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates Its Nephrotoxicity Toxicological Sciences : an Official Journal of the Society of Toxicology. Aug, 2011 | Pubmed ID: 21613233 Knockout of Hepatic P450 Reductase Aggravates Triptolide-induced Toxicity Toxicology Letters. Aug, 2011 | Pubmed ID: 21596114 [Determination of Tracer Gas Contents in Sediment Pore Water of Gas Hydrate Area by Two-dimensional Gas Chromatography] Se Pu = Chinese Journal of Chromatography / Zhongguo Hua Xue Hui. Jan, 2011 | Pubmed ID: 21574403 Hypoxia-inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis Hepatology (Baltimore, Md.). Aug, 2011 | Pubmed ID: 21538443 Intestinal Hypoxia-inducible Factor-2alpha (HIF-2alpha) is Critical for Efficient Erythropoiesis The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21498508 [Progress of the Study of Mechanism on Drug Induced Kidney Injury] Yao Xue Xue Bao = Acta Pharmaceutica Sinica. Oct, 2010 | Pubmed ID: 21348296 Emodin Triggers DNA Double-strand Breaks by Stabilizing Topoisomerase II-DNA Cleavage Complexes and by Inhibiting ATP Hydrolysis of Topoisomerase II Toxicological Sciences : an Official Journal of the Society of Toxicology. Dec, 2010 | Pubmed ID: 20855424 [Role of Na(+)-K(+)-ATPase in Lipopolysaccharide-induced Cardiomyocyte Hypertrophy in Rats] Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. Sep, 2010 | Pubmed ID: 20855249 Beta-Naphthoflavone Protects Mice from Aristolochic Acid-I-induced Acute Kidney Injury in a CYP1A Dependent Mechanism Acta Pharmacologica Sinica. Nov, 2009 | Pubmed ID: 19890363 [Changes in the MRNA Expressions of Myocardial Cytoskeletal Proteins in Endotoxemic Rats] Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. Jun, 2009 | Pubmed ID: 19726336 The Relationship Between Diphenylamine Structure and NSAIDs-induced Hepatocytes Injury Toxicology Letters. Apr, 2009 | Pubmed ID: 19429231 Comparative 28-day Repeated Oral Toxicity of Longdan Xieganwan, Akebia Trifoliate (Thunb.) Koidz., Akebia Quinata (Thunb.) Decne. and Caulis Aristolochiae Manshuriensis in Mice Journal of Ethnopharmacology. Sep, 2008 | Pubmed ID: 18582552 Roles of Reactive Oxygen Species and MAP Kinases in the Primary Rat Hepatocytes Death Induced by Toosendanin Toxicology. Jul, 2008 | Pubmed ID: 18499325 Induction of P450 1A by 3-methylcholanthrene Protects Mice from Aristolochic Acid-I-induced Acute Renal Injury Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2008 | Pubmed ID: 18495746 Baicalin Inhibits Macrophage Activation by Lipopolysaccharide and Protects Mice from Endotoxin Shock Biochemical Pharmacology. Feb, 2008 | Pubmed ID: 18191816 Thermal Cyclodehydrogenations to Form 6-membered Rings: Cyclizations of [5]helicenes Organic Letters. Sep, 2007 | Pubmed ID: 17760450 Role of Mitochondrial Permeability Transition in Human Renal Tubular Epithelial Cell Death Induced by Aristolochic Acid Toxicology and Applied Pharmacology. Jul, 2007 | Pubmed ID: 17521691 Baicalin Protects Mouse from Concanavalin A-induced Liver Injury Through Inhibition of Cytokine Production and Hepatocyte Apoptosis Liver International : Official Journal of the International Association for the Study of the Liver. May, 2007 | Pubmed ID: 17403198 [Effects of Sowing Times on the Spike Differentiation of Different Wheat Varieties Under the Climate of Warm Winter] Ying Yong Sheng Tai Xue Bao = The Journal of Applied Ecology / Zhongguo Sheng Tai Xue Xue Hui, Zhongguo Ke Xue Yuan Shenyang Ying Yong Sheng Tai Yan Jiu Suo Zhu Ban. Oct, 2003 | Pubmed ID: 14986353 Altered Expression of Vascular Endothelial Growth Factor and Its Receptors in Normal Saphenous Vein and in Arterialized and Stenotic Vein Grafts American Journal of Surgery. Nov, 2003 | Pubmed ID: 14599626 Differential Gene Expression in Primary and Recurrent Carotid Stenosis Biochemical and Biophysical Research Communications. Mar, 2003 | Pubmed ID: 12615063 Hydrothermal Preparation of Novel Cd(II) Coordination Polymers Employing 5-(4-pyridyl)tetrazolate As a Bridging Ligand Inorganic Chemistry. Dec, 2002 | Pubmed ID: 12470047 Novel, Acentric Metal-organic Coordination Polymers from Hydrothermal Reactions Involving in Situ Ligand Synthesis Angewandte Chemie (International Ed. in English). Oct, 2002 | Pubmed ID: 12386852 A Cluster Rearrangement of an Open Cubane (Cu4Br4) to a Prismane (Cu6Br6) in a Copper(I)-olefin Network Angewandte Chemie (International Ed. in English). Aug, 2002 | Pubmed ID: 12203419 Two Chiral Coordination Polymers: Preparation and X-ray Structures of Mono(4-sulfo-L-phenylalanine)(diaqua) Zinc(II) and Copper(II) Complexes Inorganic Chemistry. Jun, 2002 | Pubmed ID: 12055012 الكشف عن مجموع أنواع الأكسجين التفاعلي في الخلايا المنضمة من قبل 2'،7'-ديكلوروديدروفلوريسين Diacetate تلطيخ Hyeoncheol Kim1, Xiang Xue1 1Department of Biochemistry and Molecular Biology, University of New Mexico JoVE 60682 Biochemistry في المختبر الثقافة عضوي من أورام القولون ماوس Xiang Xue1, Yatrik M. Shah1,2 1Department of Molecular & Integrative Physiology, University of Michigan, 2Department of Internal Medicine, Division of Gastroenterology, University of Michigan JoVE 50210 Medicine
الكشف عن مجموع أنواع الأكسجين التفاعلي في الخلايا المنضمة من قبل 2'،7'-ديكلوروديدروفلوريسين Diacetate تلطيخ Hyeoncheol Kim1, Xiang Xue1 1Department of Biochemistry and Molecular Biology, University of New Mexico JoVE 60682 Biochemistry
في المختبر الثقافة عضوي من أورام القولون ماوس Xiang Xue1, Yatrik M. Shah1,2 1Department of Molecular & Integrative Physiology, University of Michigan, 2Department of Internal Medicine, Division of Gastroenterology, University of Michigan JoVE 50210 Medicine