Xiaolei Xu Biography Publications JoVE Articles Xiaolei Xu has not added a biography. If you are Xiaolei Xu and would like to personalize this page please email our Author Liaison for assistance. Publications Allelic Heterogeneity of TTNtv Cardiomyopathy Can Be Modeled in Adult Zebrafish JCI Insight. Feb, 2024 | Pubmed ID: 38412038 Zbtb16 Increases Susceptibility of Atrial Fibrillation in Type 2 Diabetic Mice Via Txnip-Trx2 Signaling Cellular and Molecular Life Sciences : CMLS. Feb, 2024 | Pubmed ID: 38349408 Premature Senescence and Cardiovascular Disease Following Cancer Treatments: Mechanistic Insights Frontiers in Cardiovascular Medicine. 2023 | Pubmed ID: 37781317 Kidney Transcriptome and Cystic Kidney Disease Genes in Zebrafish Frontiers in Physiology. 2023 | Pubmed ID: 37256068 Molecular Mechanisms of Anthracycline Induced Cardiotoxicity: Zebrafish Come into Play Frontiers in Cardiovascular Medicine. 2023 | Pubmed ID: 36970353 Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy International Journal of Molecular Sciences. Feb, 2023 | Pubmed ID: 36835518 Transcriptome Studies of Inherited Dilated Cardiomyopathies Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2023 | Pubmed ID: 36749382 Application of an F0-based Genetic Assay in Adult Zebrafish to Identify Modifier Genes of an Inherited Cardiomyopathy Disease Models & Mechanisms. May, 2023 | Pubmed ID: 35481478 Radiation Therapy Induces Immunosenescence Mediated by P90RSK Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 36426217 Genetic Therapy in a Mitochondrial Disease Model Suggests a Critical Role for Liver Dysfunction in Mortality ELife. Nov, 2022 | Pubmed ID: 36408801 A Phenotype-based Forward Genetic Screen Identifies As a Sick Sinus Syndrome Gene ELife. Oct, 2022 | Pubmed ID: 36255053 A Missense Mutation in the Proprotein Convertase Gene Furinb Causes Hepatic Cystogenesis During Liver Development in Zebrafish Hepatology Communications. Nov, 2022 | Pubmed ID: 36017776 Genetic Susceptibility and Mechanisms Underlying the Pathogenesis of Anthracycline-Associated Cardiotoxicity Oxidative Medicine and Cellular Longevity. 2022 | Pubmed ID: 35965684 A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish Genes. Jul, 2022 | Pubmed ID: 35893052 Vascular Injury in the Zebrafish Tail Modulates Blood Flow and Peak Wall Shear Stress to Restore Embryonic Circular Network Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 35369301 Corrigendum to 'Induction of Wnt Signaling Antagonists and P21-activated Kinase Enhances Cardiomyocyte Proliferation During Zebrafish Heart Regeneration' Journal of Molecular Cell Biology. Jan, 2022 | Pubmed ID: 35092682 A Novel Wireless ECG System for Prolonged Monitoring of Multiple Zebrafish for Heart Disease and Drug Screening Studies Biosensors & Bioelectronics. Feb, 2022 | Pubmed ID: 34801796 Inhibition of MTOR or MAPK Ameliorates Vmhcl/myh7 Cardiomyopathy in Zebrafish JCI Insight. Dec, 2021 | Pubmed ID: 34935644 Changes in Ion Channel Expression and Function Associated with Cardiac Arrhythmogenic Remodeling by Sorbs2 Biochimica Et Biophysica Acta. Molecular Basis of Disease. Dec, 2021 | Pubmed ID: 34487812 A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models Bio-protocol. Aug, 2021 | Pubmed ID: 34458408 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity Circulation Research. Oct, 2021 | Pubmed ID: 34384247 Disruption of Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure BioMed Research International. 2021 | Pubmed ID: 34327238 Deep Learning-based Framework for Cardiac Function Assessment in Embryonic Zebrafish from Heart Beating Videos Computers in Biology and Medicine. Aug, 2021 | Pubmed ID: 34157469 TFEB Overexpression, Not MTOR Inhibition, Ameliorates RagC Cardiomyopathy International Journal of Molecular Sciences. May, 2021 | Pubmed ID: 34071043 Induction of Wnt Signaling Antagonists and P21-activated Kinase Enhances Cardiomyocyte Proliferation During Zebrafish Heart Regeneration Journal of Molecular Cell Biology. Apr, 2021 | Pubmed ID: 33582796 Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish Mutants Journal of the American Society of Nephrology : JASN. Apr, 2021 | Pubmed ID: 33574160 Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine Frontiers in Physiology. 2020 | Pubmed ID: 33329049 Continuous Electrocardiogram Monitoring in Zebrafish with Prolonged Mild Anesthesia Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Jul, 2020 | Pubmed ID: 33018541 Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy Journal of the American Heart Association. Sep, 2020 | Pubmed ID: 32808564 Building the Vertebrate Codex Using the Gene Breaking Protein Trap Library ELife. 08, 2020 | Pubmed ID: 32779569 A Feasibility Study for Noninvasive Measurement of Shear Wave Speed in Live Zebrafish Ultrasonics. Sep, 2020 | Pubmed ID: 32417695 Aging-associated Sinus Arrest and Sick Sinus Syndrome in Adult Zebrafish PloS One. 2020 | Pubmed ID: 32401822 Retinoid X Receptor Alpha is a Spatiotemporally Predominant Therapeutic Target for Anthracycline-induced Cardiotoxicity Science Advances. Jan, 2020 | Pubmed ID: 32064346 Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish IEEE Sensors Journal. Jun, 2019 | Pubmed ID: 32855627 Haploinsufficiency of Mechanistic Target of Rapamycin Ameliorates Cardiomyopathy in Adult Zebrafish Disease Models & Mechanisms. Oct, 2019 | Pubmed ID: 31492659 Phenotyping an Adult Zebrafish Lamp2 Cardiomyopathy Model Identifies MTOR Inhibition As a Candidate Therapy Journal of Molecular and Cellular Cardiology. Aug, 2019 | Pubmed ID: 31228518 Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Susceptibility to Doxorubicin-induced Injury and Regeneration JCI Insight. Apr, 2019 | Pubmed ID: 30996130 A Langendorff-like System to Quantify Cardiac Pump Function in Adult Zebrafish Disease Models & Mechanisms. Sep, 2018 | Pubmed ID: 30012855 Phenotyping Cardiomyopathy in Adult Zebrafish Progress in Biophysics and Molecular Biology. Oct, 2018 | Pubmed ID: 29884423 Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection Sensors (Basel, Switzerland). Dec, 2017 | Pubmed ID: 29283402 Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair Scientific Reports. Aug, 2017 | Pubmed ID: 28819303 Recessive TAF1A Mutations Reveal Ribosomopathy in Siblings with End-stage Pediatric Dilated Cardiomyopathy Human Molecular Genetics. Aug, 2017 | Pubmed ID: 28472305 Systematic Identification and Characterization of Cardiac Long Intergenic Noncoding RNAs in Zebrafish Scientific Reports. 04, 2017 | Pubmed ID: 28455512 Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28358314 Autophagy Activators Suppress Cystogenesis in an Autosomal Dominant Polycystic Kidney Disease Model Human Molecular Genetics. Jan, 2017 | Pubmed ID: 28007903 Modeling -Associated Dilated Cardiomyopathy in Adult Zebrafish Journal of Cardiovascular Development and Disease. Mar, 2016 | Pubmed ID: 28955713 Exon- and Contraction-dependent Functions of Titin in Sarcomere Assembly Development (Cambridge, England). Nov, 2016 | Pubmed ID: 27836965 A Modifier Screen Identifies As a Cardiomyopathy Susceptibility Gene JCI Insight. Sep, 2016 | Pubmed ID: 27642634 Effects of Ventricular Conduction Block Patterns on Mortality in Hospitalized Patients with Dilated Cardiomyopathy: a Single-center Cohort Study BMC Cardiovascular Disorders. Jun, 2016 | Pubmed ID: 27296108 De Novo RRAGC Mutation Activates MTORC1 Signaling in Syndromic Fetal Dilated Cardiomyopathy Human Genetics. Aug, 2016 | Pubmed ID: 27234373 Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function Scientific Reports. Mar, 2016 | Pubmed ID: 26935567 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Both Ciliary and Non-ciliary Functions of Foxj1a Confer Wnt/β-catenin Signaling in Zebrafish Left-right Patterning Biology Open. 2015 | Pubmed ID: 26432885 Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish Circulation. Cardiovascular Genetics. Apr, 2015 | Pubmed ID: 25583992 Understanding Cardiac Sarcomere Assembly with Zebrafish Genetics Anatomical Record (Hoboken, N.J. : 2007). Sep, 2014 | Pubmed ID: 25125181 Cardiac Troponin T (TNNT2) Mutations in Chinese Dilated Cardiomyopathy Patients BioMed Research International. 2014 | Pubmed ID: 25110706 Cessation of Contraction Induces Cardiomyocyte Remodeling During Zebrafish Cardiogenesis American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2014 | Pubmed ID: 24322613 Anti-remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade PloS One. 2013 | Pubmed ID: 24312548 New and TALENted Genome Engineering Toolbox Circulation Research. Aug, 2013 | Pubmed ID: 23948583 Trapping Cardiac Recessive Mutants Via Expression-based Insertional Mutagenesis Screening Circulation Research. Feb, 2013 | Pubmed ID: 23283723 사용 및 Autophagy 모니터링 분석 실험의 해석에 대 한 지침 Autophagy. Apr, 2012 | Pubmed ID: 22966490 Target of Rapamycin (TOR)-based Therapy for Cardiomyopathy: Evidence from Zebrafish and Human Studies Trends in Cardiovascular Medicine. Feb, 2012 | Pubmed ID: 22841839 α-Actinin2 is Required for the Lateral Alignment of Z Discs and Ventricular Chamber Enlargement During Zebrafish Cardiogenesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2012 | Pubmed ID: 22767232 Rapamcyin (TOR)의 대상-심장 근육 병 증에 대 한 치료제를 기반: Zebrafish 유전학에서 통찰력 Cell Cycle (Georgetown, Tex.). Feb, 2012 | Pubmed ID: 22262179 배아와 성인 Zebrafish 심장 기능을 측정 합니다 Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22222517 Foxj1 표현과 Zebrafish Kupffer 소포에 Ciliogenesis 조절 직접 Wnt/β-catenin 신호 Development (Cambridge, England). Feb, 2012 | Pubmed ID: 22190638 토르-autophagy 심장 근육 병 증의 성인 Zebrafish 모델에 신호 Autophagy. Jan, 2012 | Pubmed ID: 22186229 심장 근육 병 증의 빈 혈 유발 Zebrafish 모델에서 Wnt/β-catenin 통로의 함수 종속 위치는 Biochemical and Biophysical Research Communications. Nov, 2011 | Pubmed ID: 22056559 Rapamycin의 대상의 Haploinsufficiency Cardiomyopathies 성인 Zebrafish의 약화 Circulation Research. Sep, 2011 | Pubmed ID: 21757652 Vivo에서 단백질 트래핑 기능 식 Codex 척추 프로테옴의 생성 Nature Methods. Jun, 2011 | Pubmed ID: 21552255 캐스케이드 Benzylation Cyclization 프로세스에 의해 Xanthenes 9 대체의 철 촉매, 전자 레인지 승진, 한 냄비 합성 Organic Letters. Jan, 2010 | Pubmed ID: 19938841 [효과 쥐에서 비타민 A 대사에 철 분 결핍] Wei Sheng Yan Jiu = Journal of Hygiene Research. Sep, 2009 | Pubmed ID: 19877508 Zebrafish Tcap의 고갈 Sarcomere 막 상호 작용, Sarcomere 어셈블리가 아니라 방해를 통해 근 위축 증으로 이어집니다 Human Molecular Genetics. Nov, 2009 | Pubmed ID: 19679566 심장 비 대 Myocyte 비 대 및 빈 혈 Zebrafish의 증식을 포함 한다 PloS One. 2009 | Pubmed ID: 19672293 개발 Zebrafish 마음에 Myofibrillogenesis: Tnnt2의 기능 연구 Developmental Biology. Jul, 2009 | Pubmed ID: 19427304 Zebrafish 심 실 Myosin 무거운 체인 (vmhc) 모터의 과도 하 고 유전자 변형 분석: 우 심 실-특정 유전자 발현의 억제 메커니즘 Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jun, 2009 | Pubmed ID: 19322764 Wnt/베타-catenin 신호 KV 개발 및 심장 비대칭성에의 독특한 기능 Development (Cambridge, England). Jan, 2009 | Pubmed ID: 19103803 [효과 다이어트에 높은 철의 철 분 수치 및 쥐에서 Hepcidin MRNA 식 수준에] Wei Sheng Yan Jiu = Journal of Hygiene Research. Jul, 2008 | Pubmed ID: 18839536 Zebrafish 필수 및 규제 Myosin 빛 체인의 고갈 고유 메커니즘을 통해 심장 기능을 감소 시킨다 Cardiovascular Research. Jul, 2008 | Pubmed ID: 18343897 Wnt3a Rhombomere 6에에서 시스테인이 풍부한 장 단백질 2의 식 변조 하 여 심장 신경 크레스트 세포 개발을 규제 한다 Circulation Research. Apr, 2008 | Pubmed ID: 18292601 Neuropilin-1 내 피 세포 생존 촉진 P53/caspases 축 변조 PloS One. 2007 | Pubmed ID: 18000534 Med10의 고갈 Wnt를 강화 하 고 Nodal Zebrafish Embryogenesis 동안 신호를 표시 하지 않습니다 Developmental Biology. Mar, 2007 | Pubmed ID: 17208216 Zebrafish Titin의 고갈 A 밴드와 Z 디스크의 어셈블리를 방해 하 여 심장 수축 감소 Circulation Research. Feb, 2007 | Pubmed ID: 17170364 RGS GAIP 작용 단백질의 C 말단 신생 하는 동안 신호 Neuropilin 1 중재 뜻하지 않습니다 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2006 | Pubmed ID: 16754745 Titin, 근육 임 단백질과 Telethonin Hypertrophic 심장 근육 병 증 관련 돌연변이 관련 된 유전자 형 관계 Molecular Genetics and Metabolism. May, 2006 | Pubmed ID: 16352453 수정 되지 않은 Prolactin의 다양 한 생물 학적 효과 및 Phosphorylated Prolactin의 분자 모방 해야 하는 서로 다른 신호 경로 Biochemistry. Jun, 2003 | Pubmed ID: 12809512 Opposite Effects of Unmodified Prolactin and a Molecular Mimic of Phosphorylated Prolactin on Morphology and the Expression of Prostate Specific Genes in the Normal Rat Prostate The Prostate. Jan, 2003 | Pubmed ID: 12481252 모성 Prolactin 컴포지션 영구적으로 자손에 GammadeltaT 표 피 세포의 기능에 영향을 미칠 수 있습니다 Developmental and Comparative Immunology. Nov, 2002 | Pubmed ID: 12377224 Pseudophosphorylated Prolactin (S179D PRL)의 성장을 억제 하 고 쥐 유선에서에서 베타-카 세 인 유전자 발현을 촉진 Cell and Tissue Research. Sep, 2002 | Pubmed ID: 12195299 Zebrafish Titin의 양자 택일로 접합된 Exon에 돌연변이 때문에 심장 근육 병 증 Nature Genetics. Feb, 2002 | Pubmed ID: 11788825 An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality JoVE 66500 Medicine 성인 제 브라에서 독 소 루비 유발 심근 모델 Xiao Ma*1,2,3, Yonghe Ding*2,3, Yong Wang2,3,4, Xiaolei Xu1,2,3 1Clinical and Translational Sciences Track, Mayo Clinic Graduate School of Biomedical Sciences, 2Department of Biochemistry and Molecular Biology, Mayo Clinic, 3Division of Cardiovascular Diseases, Mayo Clinic, 4Institute of Life Science, Beijing University of Chinese Medicine JoVE 57567 Medicine 해부 Zebrafish 배아 심장의 Immunostaining Jingchun Yang1, Xiaolei Xu1 1Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine JoVE 3510 Biology
An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality JoVE 66500 Medicine
성인 제 브라에서 독 소 루비 유발 심근 모델 Xiao Ma*1,2,3, Yonghe Ding*2,3, Yong Wang2,3,4, Xiaolei Xu1,2,3 1Clinical and Translational Sciences Track, Mayo Clinic Graduate School of Biomedical Sciences, 2Department of Biochemistry and Molecular Biology, Mayo Clinic, 3Division of Cardiovascular Diseases, Mayo Clinic, 4Institute of Life Science, Beijing University of Chinese Medicine JoVE 57567 Medicine
해부 Zebrafish 배아 심장의 Immunostaining Jingchun Yang1, Xiaolei Xu1 1Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine JoVE 3510 Biology