Xiaoxin Chen Cancer Research Program North Carolina Central University Biography Publications Institution JoVE Articles Xiaoxin Chen has not added a biography. If you are Xiaoxin Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity Journal of Medicinal Chemistry. Aug, 2015 | Pubmed ID: 26204233 Personalized Targeted Therapy for Esophageal Squamous Cell Carcinoma World Journal of Gastroenterology : WJG. Jul, 2015 | Pubmed ID: 26167067 The Recyclable Synthesis of Hierarchical Zeolite SAPO-34 with Excellent MTO Catalytic Performance Chemical Communications (Cambridge, England). Jul, 2015 | Pubmed ID: 26121259 Quantitative Risk Stratification of Oral Leukoplakia with Exfoliative Cytology PloS One. 2015 | Pubmed ID: 25978541 A Case of Late-onset Riboflavin Responsive Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) with a Novel Mutation in ETFDH Gene Journal of the Neurological Sciences. Jun, 2015 | Pubmed ID: 25913573 Mycoplasma Pneumonia Combined with Pulmonary Infarction in a Child International Journal of Clinical and Experimental Medicine. 2015 | Pubmed ID: 25785159 Molecular Mechanisms of Ethanol-associated Oro-esophageal Squamous Cell Carcinoma Cancer Letters. Jun, 2015 | Pubmed ID: 25766659 Surveying Mercury Levels in Hair, Blood and Urine of Under 7-year Old Children from a Coastal City in China International Journal of Environmental Research and Public Health. Nov, 2014 | Pubmed ID: 25419876 Translational Research on Barrett's Esophagus Annals of the New York Academy of Sciences. Sep, 2014 | Pubmed ID: 25266024 Pharmacological Effects of the Water Fraction of Key Components in the Traditional Chinese Prescription Mai Tong Fang on 3T3-L1 Adipocytes and Ob/ob Diabetic Mice Molecules (Basel, Switzerland). 2014 | Pubmed ID: 25230123 Ginger Compound [6]-shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo Chemical Research in Toxicology. Sep, 2014 | Pubmed ID: 25148906 Markers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Esophagitis and Proton Pump Inhibitor-responsive Esophageal Eosinophilia: a Prospective Study Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Dec, 2014 | Pubmed ID: 24993367 Anti-tumor Activity and Safety Evaluation of Fisetin-loaded Methoxy Poly(ethylene Glycol)-poly(epsilon-caprolactone) Nanoparticles Journal of Biomedical Nanotechnology. Apr, 2014 | Pubmed ID: 24734510 Identification and Pharmacokinetics of Novel Alkylresorcinol Metabolites in Human Urine, New Candidate Biomarkers for Whole-grain Wheat and Rye Intake The Journal of Nutrition. Feb, 2014 | Pubmed ID: 24259554 Single Nucleotide Polymorphisms of Caudal Type Homeobox 1 and 2 Are Associated with Barrett's Esophagus Digestive Diseases and Sciences. Jan, 2014 | Pubmed ID: 23918153 Nrf2 Deficiency Impairs the Barrier Function of Mouse Oesophageal Epithelium Gut. May, 2014 | Pubmed ID: 23676441 NFkB and Nrf2 in Esophageal Epithelial Barrier Function Tissue Barriers. Dec, 2013 | Pubmed ID: 24790804 Tissue Resistance in the Normal and Diseased Esophagus Annals of the New York Academy of Sciences. Oct, 2013 | Pubmed ID: 24117643 Cellular Origins and Molecular Mechanisms of Barrett's Esophagus and Esophageal Adenocarcinoma Annals of the New York Academy of Sciences. Oct, 2013 | Pubmed ID: 24117642 Transgenic Overexpression of Cdx1b Induces Metaplastic Changes of Gene Expression in Zebrafish Esophageal Squamous Epithelium Zebrafish. Jun, 2013 | Pubmed ID: 23672288 Synthesis, Characterization, and Application of Amino-terminated Poly(ethylene Glycol)-block-poly(epsilon-caprolactone) Copolymer for Paclitaxel Journal of Nanoscience and Nanotechnology. Jan, 2013 | Pubmed ID: 23646699 Gastroesophageal Reflux Activates the NF-κB Pathway and Impairs Esophageal Barrier Function in Mice American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2013 | Pubmed ID: 23639809 Cysteine-conjugated Metabolite of Ginger Component [6]-shogaol Serves As a Carrier of [6]-shogaol in Cancer Cells and in Mice Chemical Research in Toxicology. Jun, 2013 | Pubmed ID: 23638641 Two Novel Nanoscale Preparations of Micelle and Thermosensitive Hydrogel for Docetaxel to Treat Malignant Tumor Journal of Biomedical Nanotechnology. Mar, 2013 | Pubmed ID: 23620990 G Protein-coupled Receptor Kinase 6 Deficiency Promotes Angiogenesis, Tumor Progression, and Metastasis Journal of Immunology (Baltimore, Md. : 1950). May, 2013 | Pubmed ID: 23589623 Sox2 Cooperates with Inflammation-mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells Cell Stem Cell. Mar, 2013 | Pubmed ID: 23472872 Characterization of Thiol-conjugated Metabolites of Ginger Components Shogaols in Mouse and Human Urine and Modulation of the Glutathione Levels in Cancer Cells by [6]-shogaol Molecular Nutrition & Food Research. Mar, 2013 | Pubmed ID: 23322393 Intestinal Metaplasia Recurs Infrequently in Patients Successfully Treated for Barrett's Esophagus with Radiofrequency Ablation The American Journal of Gastroenterology. Feb, 2013 | Pubmed ID: 23247578 Safety and Efficacy of Endoscopic Mucosal Therapy with Radiofrequency Ablation for Patients with Neoplastic Barrett's Esophagus Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Jun, 2013 | Pubmed ID: 23103824 Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Hamster Cheek Pouch Carcinogenesis by a 5-lipoxygenase Inhibitor, Garcinol Nutrition and Cancer. 2012 | Pubmed ID: 23137051 6-gingerdiols As the Major Metabolites of 6-gingerol in Cancer Cells and in Mice and Their Cytotoxic Effects on Human Cancer Cells Journal of Agricultural and Food Chemistry. Nov, 2012 | Pubmed ID: 23066935 Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis The American Journal of Gastroenterology. Oct, 2012 | Pubmed ID: 22777338 Focal Endoscopic Mucosal Resection Before Radiofrequency Ablation is Equally Effective and Safe Compared with Radiofrequency Ablation Alone for the Eradication of Barrett's Esophagus with Advanced Neoplasia Gastrointestinal Endoscopy. Oct, 2012 | Pubmed ID: 22732872 Transcript Profiling Identifies Dynamic Gene Expression Patterns and an Important Role for Nrf2/Keap1 Pathway in the Developing Mouse Esophagus PloS One. 2012 | Pubmed ID: 22567161 Hedgehog Signaling Activation in the Development of Squamous Cell Carcinoma and Adenocarcinoma of Esophagus International Journal of Biochemistry and Molecular Biology. 2012 | Pubmed ID: 22509480 Review: Experimental Models for Barrett's Esophagus and Esophageal Adenocarcinoma American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2012 | Pubmed ID: 22421618 The Decreased Expression of Beclin-1 Correlates with Progression to Esophageal Adenocarcinoma: the Role of Deoxycholic Acid American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2012 | Pubmed ID: 22301112 Metabolism of [6]-shogaol in Mice and in Cancer Cells Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2012 | Pubmed ID: 22246389 Time-selective Chemoprevention of Vitamin E and Selenium on Esophageal Carcinogenesis in Rats: the Possible Role of Nuclear Factor KappaB Signaling Pathway International Journal of Cancer. Journal International Du Cancer. Oct, 2012 | Pubmed ID: 22223226 Molecular Mechanisms of Barrett's Esophagus Digestive Diseases and Sciences. Dec, 2011 | Pubmed ID: 21984436 Molecular Mechanisms of Barrett's Esophagus and Adenocarcinoma Annals of the New York Academy of Sciences. Sep, 2011 | Pubmed ID: 21950830 Molecular Aspects of Esophageal Development Annals of the New York Academy of Sciences. Sep, 2011 | Pubmed ID: 21950820 Structural Identification of Mouse Fecal Metabolites of Theaflavin 3,3'-digallate Using Liquid Chromatography Tandem Mass Spectrometry Journal of Chromatography. A. Oct, 2011 | Pubmed ID: 21906744 Ethanol Promotes Chemically Induced Oral Cancer in Mice Through Activation of the 5-lipoxygenase Pathway of Arachidonic Acid Metabolism Cancer Prevention Research (Philadelphia, Pa.). Nov, 2011 | Pubmed ID: 21881027 Chemopreventive Effects of Early-stage and Late-stage Supplementation of Vitamin E and Selenium on Esophageal Carcinogenesis in Rats Maintained on a Low Vitamin E/selenium Diet Carcinogenesis. Mar, 2011 | Pubmed ID: 21186300 Tryptase Staining of Mast Cells May Differentiate Eosinophilic Esophagitis from Gastroesophageal Reflux Disease The American Journal of Gastroenterology. Feb, 2011 | Pubmed ID: 20978486 Structural Identification of Mouse Urinary Metabolites of Pterostilbene Using Liquid Chromatography/tandem Mass Spectrometry Rapid Communications in Mass Spectrometry : RCM. Jun, 2010 | Pubmed ID: 20499322 Varying Phenotypes in Swine Versus Murine Transgenic Models Constitutively Expressing the Same Human Sonic Hedgehog Transcriptional Activator, K5-HGLI2 Delta N Transgenic Research. Oct, 2010 | Pubmed ID: 20099029 Chemoprevention of Oral Cancer in Animal Models, and Effect on Leukoplakias in Human Patients with ZengShengPing, a Mixture of Medicinal Herbs Oral Oncology. Feb, 2010 | Pubmed ID: 20022553 Zebrafish K5 Promoter Driven GFP Expression As a Transgenic System for Oral Research Oral Oncology. Jan, 2010 | Pubmed ID: 19932050 Stimuli-responsive Wettability of Nonplanar Substrates: PH-controlled Floatation and Supporting Force Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2010 | Pubmed ID: 19639980 Detecting Precancerous Lesions in the Hamster Cheek Pouch Using Spectroscopic White-light Optical Coherence Tomography to Assess Nuclear Morphology Via Spectral Oscillations Journal of Biomedical Optics. Nov-Dec, 2009 | Pubmed ID: 20059268 Gastroesophageal Reflux Leads to Esophageal Cancer in a Surgical Model with Mice BMC Gastroenterology. 2009 | Pubmed ID: 19627616 Differential Gene Expression in Normal Esophagus and Barrett's Esophagus Journal of Gastroenterology. 2009 | Pubmed ID: 19468668 Effect of Alpha-tocopherol, N-acetylcysteine and Omeprazole on Esophageal Adenocarcinoma Formation in a Rat Surgical Model International Journal of Cancer. Journal International Du Cancer. Mar, 2009 | Pubmed ID: 19058177 Zyflamend Reduces LTB4 Formation and Prevents Oral Carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced Hamster Cheek Pouch Model Carcinogenesis. Nov, 2008 | Pubmed ID: 18687669 Depletion of Beta-arrestin-2 Promotes Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18390755 Multilayered Epithelium in a Rat Model and Human Barrett's Esophagus: Similar Expression Patterns of Transcription Factors and Differentiation Markers BMC Gastroenterology. 2008 | Pubmed ID: 18190713 Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Oral Carcinogenesis in Hamster Cheek Pouch by Topical Application of a Dual Inhibitor of Epidermal Growth Factor Receptor (EGFR) and ErbB2 Tyrosine Kinases Oral Oncology. Jul, 2008 | Pubmed ID: 17936675 Identification of Arsenic-binding Proteins in Human Breast Cancer Cells Cancer Letters. Sep, 2007 | Pubmed ID: 17499915 Regulation of Cdx2 Expression by Promoter Methylation, and Effects of Cdx2 Transfection on Morphology and Gene Expression of Human Esophageal Epithelial Cells Carcinogenesis. Feb, 2007 | Pubmed ID: 16990345 Five-lipoxygenase Pathway of Arachidonic Acid Metabolism in Carcino-genesis and Cancer Chemoprevention Current Cancer Drug Targets. Nov, 2006 | Pubmed ID: 17100567 Determination of Endogenous Tissue Inflammation Profiles by LC/MS/MS: COX- and LOX-derived Bioactive Lipids Prostaglandins, Leukotrienes, and Essential Fatty Acids. Dec, 2006 | Pubmed ID: 17011176 Development of an Immunocytokine, IL-2-183B2scFv, for Targeted Immunotherapy of Ovarian Cancer Gynecologic Oncology. Dec, 2006 | Pubmed ID: 16806435 Involvement of the 5-lipoxygenase/leukotriene A4 Hydrolase Pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced Oral Carcinogenesis in Hamster Cheek Pouch, and Inhibition of Carcinogenesis by Its Inhibitors Carcinogenesis. Sep, 2006 | Pubmed ID: 16632477 Selection of Topically Applied Non-steroidal Anti-inflammatory Drugs for Oral Cancer Chemoprevention Oral Oncology. Jul, 2005 | Pubmed ID: 15975519 Overexpression of 5-lipoxygenase and Cyclooxygenase 2 in Hamster and Human Oral Cancer and Chemopreventive Effects of Zileuton and Celecoxib Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2005 | Pubmed ID: 15756036 Overexpression of 5-lipoxygenase in Rat and Human Esophageal Adenocarcinoma and Inhibitory Effects of Zileuton and Celecoxib on Carcinogenesis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004 | Pubmed ID: 15475461 Phenotype of Columnar-lined Esophagus in Rats with Esophagogastroduodenal Anastomosis: Similarity to Human Barrett's Esophagus Laboratory Investigation; a Journal of Technical Methods and Pathology. Jun, 2004 | Pubmed ID: 15094711 Modulation of Arachidonic Acid Metabolism by Curcumin and Related Beta-diketone Derivatives: Effects on Cytosolic Phospholipase A(2), Cyclooxygenases and 5-lipoxygenase Carcinogenesis. Sep, 2004 | Pubmed ID: 15073046 Leukotriene A4 Hydrolase in Rat and Human Esophageal Adenocarcinomas and Inhibitory Effects of Bestatin Journal of the National Cancer Institute. Jul, 2003 | Pubmed ID: 12865451 [Chemopreventive Effect of Tea and Curcumin on DMBA-induced Oral Carcinogenesis in Hamsters] Wei Sheng Yan Jiu = Journal of Hygiene Research. Oct, 2002 | Pubmed ID: 12572355 Aberrant Arachidonic Acid Metabolism in Esophageal Adenocarcinogenesis, and the Effects of Sulindac, Nordihydroguaiaretic Acid, and Alpha-difluoromethylornithine on Tumorigenesis in a Rat Surgical Model Carcinogenesis. Dec, 2002 | Pubmed ID: 12507933 Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Oral Carcinogenesis in Hamsters by Tea and Curcumin Carcinogenesis. Aug, 2002 | Pubmed ID: 12151348 Overexpression of Glucose-regulated Protein 94 (Grp94) in Esophageal Adenocarcinomas of a Rat Surgical Model and Humans Carcinogenesis. Jan, 2002 | Pubmed ID: 11756233 Kirurgiske modeller af gastroøsofageal refluks med Mus Jinxi He1,2, Yu Fang2,3, Xiaoxin Chen2,4 1Department of Thoracic Surgery, Ningxia Medical University General Hospital, 2Cancer Research Program, North Carolina Central University, 3Department of Thoracic & Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, 4Department of Medicine, Center for Esophageal Disease and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill Medicine
Kirurgiske modeller af gastroøsofageal refluks med Mus Jinxi He1,2, Yu Fang2,3, Xiaoxin Chen2,4 1Department of Thoracic Surgery, Ningxia Medical University General Hospital, 2Cancer Research Program, North Carolina Central University, 3Department of Thoracic & Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, 4Department of Medicine, Center for Esophageal Disease and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill Medicine