Yale E. Goldman

Publications

• Processivity and Velocity for Motors Stepping On Periodic Tracks
  Biophysical Journal. Apr, 2020  |   Pubmed ID: 32367805
• Straightening Out the Elasticity of Myosin Cross-Bridges
  Biophysical Journal. Mar, 2020  |   Pubmed ID: 31968230
• Nanoaperture Fabrication Via Colloidal Lithography for Single Molecule Fluorescence Analysis
  PloS One. 2019  |   Pubmed ID: 31600217
• Single Molecule Mechanics Resolves the Earliest Events in Force Generation by Cardiac Myosin
  ELife. 09, 2019  |   Pubmed ID: 31526481
• New Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery
  ACS Medicinal Chemistry Letters. Dec, 2018  |   Pubmed ID: 30613341
• Positive Cardiac Inotrope Omecamtiv Mecarbil Activates Muscle Despite Suppressing the Myosin Working Stroke
  Nature Communications. 09, 2018  |   Pubmed ID: 30242219
• E. Coli Elongation Factor Tu Bound to a GTP Analogue Displays an Open Conformation Equivalent to the GDP-bound Form
  Nucleic Acids Research. 09, 2018  |   Pubmed ID: 30107565
• Structural Dynamics of Translation Elongation Factor Tu During Aa-tRNA Delivery to the Ribosome
  Nucleic Acids Research. Sep, 2018  |   Pubmed ID: 30107527
• Translocation Kinetics and Structural Dynamics of Ribosomes Are Modulated by the Conformational Plasticity of Downstream Pseudoknots
  Nucleic Acids Research. 10, 2018  |   Pubmed ID: 30011005
• Electro-optic Deflectors Deliver Advantages over Acousto-optical Deflectors in a High Resolution, Ultra-fast Force-clamp Optical Trap
  Optics Express. Apr, 2018  |   Pubmed ID: 29716042
• The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility
  Biophysical Journal. 03, 2018  |   Pubmed ID: 29590597
• TRNA Fluctuations Observed on Stalled Ribosomes Are Suppressed During Ongoing Protein Synthesis
  Biophysical Journal. Dec, 2017  |   Pubmed ID: 29211986
• Angular Measurements of the Dynein Ring Reveal a Stepping Mechanism Dependent on a Flexible Stalk
  Proceedings of the National Academy of Sciences of the United States of America. 06, 2017  |   Pubmed ID: 28533393
• Deconvolution of Camera Instrument Response Functions
  Biophysical Journal. Mar, 2017  |   Pubmed ID: 28355548
• Measuring Molecular Forces Using Calibrated Optical Tweezers in Living Cells
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 27844443
• Single Molecule Optical Measurements of Orientation and Rotations of Biological Macromolecules
  Methods and Applications in Fluorescence. 11, 2016  |   Pubmed ID: 28192292
• MEMLET: An Easy-to-Use Tool for Data Fitting and Model Comparison Using Maximum-Likelihood Estimation
  Biophysical Journal. Jul, 2016  |   Pubmed ID: 27463130
• Elongation Factor G Initiates Translocation Through a Power Stroke
  Proceedings of the National Academy of Sciences of the United States of America. 07, 2016  |   Pubmed ID: 27313204
• NeutrAvidin Functionalization of CdSe/CdS Quantum Nanorods and Quantification of Biotin Binding Sites Using Biotin-4-Fluorescein Fluorescence Quenching
  Bioconjugate Chemistry. Mar, 2016  |   Pubmed ID: 26722835
• EF-Tu Dynamics During Pre-translocation Complex Formation: EF-Tu·GDP Exits the Ribosome Via Two Different Pathways
  Nucleic Acids Research. Oct, 2015  |   Pubmed ID: 26338772
• Labeled EF-Tus for Rapid Kinetic Studies of Pretranslocation Complex Formation
  ACS Chemical Biology. Oct, 2014  |   Pubmed ID: 25126896
• Reconstituting the Motility of Isolated Intracellular Cargoes
  Methods in Enzymology. 2014  |   Pubmed ID: 24630111
• Quantifying Elongation Rhythm During Full-Length Protein Synthesis
  Journal of the American Chemical Society. Jul, 2013  |   Pubmed ID: 23822614
• Local Cytoskeletal and Organelle Interactions Impact Molecular-motor- Driven Early Endosomal Trafficking
  Current Biology : CB. Jul, 2013  |   Pubmed ID: 23770188
• Tb(3+)-tRNA for LRET Studies of Protein Synthesis
  Bioconjugate Chemistry. Jul, 2013  |   Pubmed ID: 23734598
• Dynamics of Translation by Single Ribosomes Through MRNA Secondary Structures
  Nature Structural & Molecular Biology. May, 2013  |   Pubmed ID: 23542154
• Tilting and Wobble of Myosin V by High-speed Single-molecule Polarized Fluorescence Microscopy
  Biophysical Journal. Mar, 2013  |   Pubmed ID: 23528086
• Orienting Actin Filaments for Directional Motility of Processive Myosin Motors
  Nano Letters. Jan, 2013  |   Pubmed ID: 23240631
• Force Measurements on Cargoes in Living Cells Reveal Collective Dynamics of Microtubule Motors
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012  |   Pubmed ID: 23091040
• Sites of Glucose Transporter-4 Vesicle Fusion with the Plasma Membrane Correlate Spatially with Microtubules
  PloS One. 2012  |   Pubmed ID: 22916292
• Myosin IC Generates Power over a Range of Loads Via a New Tension-sensing Mechanism
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012  |   Pubmed ID: 22908250
• Nanoscale Topography Mediates the Adhesion of F-actin
  Langmuir : the ACS Journal of Surfaces and Colloids. Aug, 2012  |   Pubmed ID: 22839968
• Force-dependent Detachment of Kinesin-2 Biases Track Switching at Cytoskeletal Filament Intersections
  Biophysical Journal. Jul, 2012  |   Pubmed ID: 22828331
• Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped Following a Mechanical Perturbation
  PloS One. 2012  |   Pubmed ID: 22761792
• Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration
  Current Biology : CB. Aug, 2012  |   Pubmed ID: 22748316
• Andrew Fielding Huxley (1917-2012)
  Nature. Jun, 2012  |   Pubmed ID: 22739307
• FRET-based Identification of MRNAs Undergoing Translation
  PloS One. 2012  |   Pubmed ID: 22693619
• Kinetic Schemes for Post-synchronized Single Molecule Dynamics
  Biophysical Journal. Mar, 2012  |   Pubmed ID: 22455931
• Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends
  Current Biology : CB. Apr, 2012  |   Pubmed ID: 22445300
• Real-time Assay for Testing Components of Protein Synthesis
  Nucleic Acids Research. Jul, 2012  |   Pubmed ID: 22422844
• The Azimuthal Path of Myosin V and Its Dependence on Lever-arm Length
  The Journal of General Physiology. Feb, 2012  |   Pubmed ID: 22291144
• Allosteric Vs. Spontaneous Exit-site (E-site) TRNA Dissociation Early in Protein Synthesis
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011  |   Pubmed ID: 21969541
• The Conserved Protein EF4 (LepA) Modulates the Elongation Cycle of Protein Synthesis
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011  |   Pubmed ID: 21930951
• Lever-arm Mechanics of Processive Myosins
  Biophysical Journal. Jul, 2011  |   Pubmed ID: 21723809
• Single-molecule Fluorescence Measurements of Ribosomal Translocation Dynamics
  Molecular Cell. May, 2011  |   Pubmed ID: 21549313
• Changepoint Analysis for Single-molecule Polarized Total Internal Reflection Fluorescence Microscopy Experiments
  Methods in Enzymology. 2011  |   Pubmed ID: 21187234
• Enhancement of Single-molecule Fluorescence Signals by Colloidal Silver Nanoparticles in Studies of Protein Translation
  ACS Nano. Jan, 2011  |   Pubmed ID: 21158483
• Comparison of Brownian-dynamics-based Estimates of Polymer Tension with Direct Force Measurements
  Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Nov, 2010  |   Pubmed ID: 21230516
• Electron Tomography of Cryofixed, Isometrically Contracting Insect Flight Muscle Reveals Novel Actin-myosin Interactions
  PloS One. Sep, 2010  |   Pubmed ID: 20844746
• Tunable Nanoscale Channels in Diblock Copolymer Films for Biomolecule Organization
  Langmuir : the ACS Journal of Surfaces and Colloids. Jul, 2010  |   Pubmed ID: 20459081
• Motor Number Controls Cargo Switching at Actin-microtubule Intersections in Vitro
  Current Biology : CB. Apr, 2010  |   Pubmed ID: 20399098
• Myosin VI Lever Arm Rotation: Fixed or Variable?
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010  |   Pubmed ID: 20393121
• Single-molecule Stepping and Structural Dynamics of Myosin X
  Nature Structural & Molecular Biology. Apr, 2010  |   Pubmed ID: 20364131
• Coordination of Molecular Motors: from in Vitro Assays to Intracellular Dynamics
  Current Opinion in Cell Biology. Feb, 2010  |   Pubmed ID: 20102789
• Drunk or Sober? Myosin V Walks the (quantum) Dotted Line in Cells
  Biophysical Journal. Jul, 2009  |   Pubmed ID: 19619454
• Using Electrical and Optical Tweezers to Facilitate Studies of Molecular Motors
  Physical Chemistry Chemical Physics : PCCP. Jun, 2009  |   Pubmed ID: 19506758
• Parallax: High Accuracy Three-dimensional Single Molecule Tracking Using Split Images
  Nano Letters. Jul, 2009  |   Pubmed ID: 19496608
• Cross-correlated TIRF/AFM Reveals Asymmetric Distribution of Force-generating Heads Along Self-assembled, "synthetic" Myosin Filaments
  Biophysical Journal. Mar, 2009  |   Pubmed ID: 19254555
• Microtubule Plus-end Tracking by CLIP-170 Requires EB1
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009  |   Pubmed ID: 19126680
• Twirling of Actin by Myosins II and V Observed Via Polarized TIRF in a Modified Gliding Assay
  Biophysical Journal. Dec, 2008  |   Pubmed ID: 18931255
• Effect of Inorganic Phosphate on the Force and Number of Myosin Cross-bridges During the Isometric Contraction of Permeabilized Muscle Fibers from Rabbit Psoas
  Biophysical Journal. Dec, 2008  |   Pubmed ID: 18835889
• Kinesin and Dynein-dynactin at Intersecting Microtubules: Motor Density Affects Dynein Function
  Biophysical Journal. Apr, 2008  |   Pubmed ID: 18227130
• Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
  Science (New York, N.Y.). Feb, 2008  |   Pubmed ID: 18202255
• Myosin VI Walks "wiggly" on Actin with Large and Variable Tilting
  Molecular Cell. Dec, 2007  |   Pubmed ID: 18158894
• Calcium Regulation of Calmodulin Binding to and Dissociation from the Myo1c Regulatory Domain
  Biochemistry. Oct, 2007  |   Pubmed ID: 17910470
• Single-molecule Structural Dynamics of EF-G--ribosome Interaction During Translocation
  Biochemistry. Sep, 2007  |   Pubmed ID: 17727272
• Confinement and Manipulation of Actin Filaments by Electric Fields
  Biophysical Journal. Oct, 2007  |   Pubmed ID: 17693465
• Functional Studies of Individual Myosin Molecules
  Annals of the New York Academy of Sciences. Oct, 2006  |   Pubmed ID: 17132771
• Processive Bidirectional Motion of Dynein-dynactin Complexes in Vitro
  Nature Cell Biology. Jun, 2006  |   Pubmed ID: 16715075
• Defocused Orientation and Position Imaging (DOPI) of Myosin V
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006  |   Pubmed ID: 16614073
• Adaptability of Myosin V Studied by Simultaneous Detection of Position and Orientation
  The EMBO Journal. May, 2006  |   Pubmed ID: 16601691
• Force Generation in Single Conventional Actomyosin Complexes Under High Dynamic Load
  Biophysical Journal. Feb, 2006  |   Pubmed ID: 16326899
• Rotational Motions of Macro-molecules by Single-molecule Fluorescence Microscopy
  Accounts of Chemical Research. Jul, 2005  |   Pubmed ID: 16028893
• Mechanical Studies of Single Ribosome/mRNA Complexes
  Biophysical Journal. Sep, 2005  |   Pubmed ID: 15951374
• Measurement of Single Macromolecule Orientation by Total Internal Reflection Fluorescence Polarization Microscopy
  Biophysical Journal. Aug, 2005  |   Pubmed ID: 15894632
• Orientation of the Myosin Light Chain Region by Single Molecule Total Internal Reflection Fluorescence Polarization Microscopy
  Biophysical Journal. Aug, 2005  |   Pubmed ID: 15894631
• Cross-bridge Number, Position, and Angle in Target Zones of Cryofixed Isometrically Active Insect Flight Muscle
  Biophysical Journal. May, 2004  |   Pubmed ID: 15111415
• Protein Synthesis by Single Ribosomes
  RNA (New York, N.Y.). Oct, 2003  |   Pubmed ID: 13130131
• Mechanism of Inhibition of Skeletal Muscle Actomyosin by N-benzyl-p-toluenesulfonamide
  Biochemistry. May, 2003  |   Pubmed ID: 12755615
• Three-dimensional Structural Dynamics of Myosin V by Single-molecule Fluorescence Polarization
  Nature. Mar, 2003  |   Pubmed ID: 12660775
• Polarized Fluorescence Depletion Reports Orientation Distribution and Rotational Dynamics of Muscle Cross-bridges
  Biophysical Journal. Aug, 2002  |   Pubmed ID: 12124286
• Orientation Changes of the Myosin Light Chain Domain During Filament Sliding in Active and Rigor Muscle
  Journal of Molecular Biology. May, 2002  |   Pubmed ID: 12083517
• Trading Force for Speed: Why Superfast Crossbridge Kinetics Leads to Superlow Forces
  Proceedings of the National Academy of Sciences of the United States of America. May, 1999  |   Pubmed ID: 10318969