Yatrik M. Shah Department of Molecular & Integrative Physiology University of Michigan Biography Publications Institution JoVE Articles Yatrik M. Shah has not added a biography. If you are Yatrik M. Shah and would like to personalize this page please email our Author Liaison for assistance. Publications Hypoxia-inducible Factor 1α Regulates a SOCS3-STAT3-adiponectin Signal Transduction Pathway in Adipocytes The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23255598 Hypoxia-inducible Factor-2α is Essential in Activating the COX2/mPGES-1/PGE2 Signaling Axis in Colon Cancer Carcinogenesis. Jan, 2013 | Pubmed ID: 23042097 Analysis of the Peroxisome Proliferator-activated Receptor-β/δ (PPARβ/δ) Cistrome Reveals Novel Co-regulatory Role of ATF4 BMC Genomics. 2012 | Pubmed ID: 23176727 Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-induced Steatohepatitis Cell Metabolism. Nov, 2012 | Pubmed ID: 23140643 The Hypoxia-inducible Factor-C/EBPα Axis Controls Ethanol-mediated Hepcidin Repression Molecular and Cellular Biology. Oct, 2012 | Pubmed ID: 22869521 Pregnane X Receptor As a Target for Treatment of Inflammatory Bowel Disorders Trends in Pharmacological Sciences. Jun, 2012 | Pubmed ID: 22609277 Decreased Hepcidin Expression in Murine β-thalassemia is Associated with Suppression of Bmp/Smad Signaling Blood. Mar, 2012 | Pubmed ID: 22461476 Hypoxia-inducible Factor-2α Activation Promotes Colorectal Cancer Progression by Dysregulating Iron Homeostasis Cancer Research. May, 2012 | Pubmed ID: 22419665 Peroxisome Proliferator-activated Receptor Alpha Induction of Uncoupling Protein 2 Protects Against Acetaminophen-induced Liver Toxicity Hepatology (Baltimore, Md.). Jul, 2012 | Pubmed ID: 22318764 The Role of Peroxisome Proliferator-activated Receptors in Carcinogenesis and Chemoprevention Nature Reviews. Cancer. Mar, 2012 | Pubmed ID: 22318237 Disruption of Endothelial Peroxisome Proliferator-activated Receptor γ Accelerates Diet-induced Atherogenesis in LDL Receptor-null Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2012 | Pubmed ID: 22015658 Disruption of Hypoxia-inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-fat Diet-fed Mice Diabetes. Oct, 2011 | Pubmed ID: 21873554 Hypoxia-inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis Hepatology (Baltimore, Md.). Aug, 2011 | Pubmed ID: 21538443 Intestinal Hypoxia-inducible Factor-2alpha (HIF-2alpha) is Critical for Efficient Erythropoiesis The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21498508 Fibrinogen-γ Proteolysis and Solubility Dynamics During Apoptotic Mouse Liver Injury: Heparin Prevents and Treats Liver Damage Hepatology (Baltimore, Md.). Apr, 2011 | Pubmed ID: 21480334 Hypoxia-inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice Gastroenterology. Jun, 2011 | Pubmed ID: 21419768 PPARalpha-dependent Activation of Cell Cycle Control and DNA Repair Genes in Hepatic Nonparenchymal Cells Toxicological Sciences : an Official Journal of the Society of Toxicology. Dec, 2010 | Pubmed ID: 20813756 Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation The Journal of Pharmacology and Experimental Therapeutics. Oct, 2010 | Pubmed ID: 20627999 Control of Steroid 21-oic Acid Synthesis by Peroxisome Proliferator-activated Receptor Alpha and Role of the Hypothalamic-pituitary-adrenal Axis The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20032461 Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid Beta-oxidation Through the Suppression of PPARalpha Activation As a Contributing Mechanism of Acetaminophen-induced Hepatotoxicity Chemical Research in Toxicology. Apr, 2009 | Pubmed ID: 19256530 Intestinal Hypoxia-inducible Transcription Factors Are Essential for Iron Absorption Following Iron Deficiency Cell Metabolism. Feb, 2009 | Pubmed ID: 19147412 A Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4 Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2008 | Pubmed ID: 18799805 Hypoxia-inducible Factor Augments Experimental Colitis Through an MIF-dependent Inflammatory Signaling Cascade Gastroenterology. Jun, 2008 | Pubmed ID: 18439915 Hepatocyte Nuclear Factor 4alpha in the Intestinal Epithelial Cells Protects Against Inflammatory Bowel Disease Inflammatory Bowel Diseases. Jul, 2008 | Pubmed ID: 18338782 Metabolomics Reveals That Hepatic Stearoyl-CoA Desaturase 1 Downregulation Exacerbates Inflammation and Acute Colitis Cell Metabolism. Feb, 2008 | Pubmed ID: 18249173 PPARalpha: Mechanism of Species Differences and Hepatocarcinogenesis of Peroxisome Proliferators Toxicology. Apr, 2008 | Pubmed ID: 18006136 Pioglitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-density Lipoprotein Receptor-null Mice Circulation. Nov, 2007 | Pubmed ID: 17967777 Rifaximin is a Gut-specific Human Pregnane X Receptor Activator The Journal of Pharmacology and Experimental Therapeutics. Jul, 2007 | Pubmed ID: 17442842 Peroxisome Proliferator-activated Receptor Alpha Regulates a MicroRNA-mediated Signaling Cascade Responsible for Hepatocellular Proliferation Molecular and Cellular Biology. Jun, 2007 | Pubmed ID: 17438130 Pregnane X Receptor Activation Ameliorates DSS-induced Inflammatory Bowel Disease Via Inhibition of NF-kappaB Target Gene Expression American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2007 | Pubmed ID: 17170021 Expression of Peroxisome Proliferator-activated Receptor-gamma in Macrophage Suppresses Experimentally Induced Colitis American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2007 | Pubmed ID: 17095756 Identification of Novel Proteins Induced by Estradiol, 4-hydroxytamoxifen and Acolbifene in T47D Breast Cancer Cells Steroids. Nov, 2006 | Pubmed ID: 16949628 Attenuation of Estrogen Receptor Alpha (ERalpha) Signaling by Selenium in Breast Cancer Cells Via Downregulation of ERalpha Gene Expression Breast Cancer Research and Treatment. Aug, 2005 | Pubmed ID: 16155795 Selenium Disrupts Estrogen Receptor (alpha) Signaling and Potentiates Tamoxifen Antagonism in Endometrial Cancer Cells and Tamoxifen-resistant Breast Cancer Cells Molecular Cancer Therapeutics. Aug, 2005 | Pubmed ID: 16093440 The Src Kinase Pathway Promotes Tamoxifen Agonist Action in Ishikawa Endometrial Cells Through Phosphorylation-dependent Stabilization of Estrogen Receptor (alpha) Promoter Interaction and Elevated Steroid Receptor Coactivator 1 Activity Molecular Endocrinology (Baltimore, Md.). Mar, 2005 | Pubmed ID: 15528270 Selective Estrogen Receptor Modulator Regulated Proteins in Endometrial Cancer Cells Molecular and Cellular Endocrinology. Apr, 2004 | Pubmed ID: 15149734 In vitro Organoid Culture of Primary Mouse Colon Tumors Xiang Xue1, Yatrik M. Shah1,2 1Department of Molecular & Integrative Physiology, University of Michigan, 2Department of Internal Medicine, Division of Gastroenterology, University of Michigan JoVE 50210 Medicine
In vitro Organoid Culture of Primary Mouse Colon Tumors Xiang Xue1, Yatrik M. Shah1,2 1Department of Molecular & Integrative Physiology, University of Michigan, 2Department of Internal Medicine, Division of Gastroenterology, University of Michigan JoVE 50210 Medicine