Zeger Debyser Molecular Virology and Gene Therapy KU Leuven Biography Publications Institution JoVE Articles Zeger Debyser has not added a biography. If you are Zeger Debyser and would like to personalize this page please email our Author Liaison for assistance. Publications HRP-2 Determines HIV-1 Integration Site Selection in LEDGF/p75 Depleted Cells Retrovirology. Oct, 2012 | Pubmed ID: 23046603 A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication PloS One. 2012 | Pubmed ID: 23028829 Preliminary Validation of Varicella Zoster Virus Thymidine Kinase As a Novel Reporter Gene for PET Nuclear Medicine and Biology. Nov, 2012 | Pubmed ID: 22981986 Cellular Cofactors of Lentiviral Integrase: from Target Validation to Drug Discovery Molecular Biology International. 2012 | Pubmed ID: 22928108 Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2) The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22872640 Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22872638 Combinational Therapies for HIV: a Focus on EVG/COBI/FTC/TDF Expert Opinion on Pharmacotherapy. Sep, 2012 | Pubmed ID: 22849516 Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2012 | Pubmed ID: 22828501 Fragment Hopping Approach Directed at Design of HIV IN-LEDGF/p75 Interaction Inhibitors Journal of Enzyme Inhibition and Medicinal Chemistry. Jul, 2012 | Pubmed ID: 22803661 Quad's in It for Antiretroviral Therapy? Lancet. Jun, 2012 | Pubmed ID: 22748575 Quantitative Evaluation of MRI-based Tracking of Ferritin-labeled Endogenous Neural Stem Cell Progeny in Rodent Brain NeuroImage. May, 2012 | Pubmed ID: 22677164 Small-molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization Antimicrobial Agents and Chemotherapy. Aug, 2012 | Pubmed ID: 22664975 Galectin-1 in Melanoma Biology and Related Neo-angiogenesis Processes The Journal of Investigative Dermatology. Sep, 2012 | Pubmed ID: 22622427 Development of a Series of 3-hydroxyquinolin-2(1H)-ones As Selective Inhibitors of HIV-1 Reverse Transcriptase Associated RNase H Activity Bioorganic & Medicinal Chemistry Letters. Jun, 2012 | Pubmed ID: 22607675 Discovery of Small Molecule HIV-1 Integrase Dimerization Inhibitors Bioorganic & Medicinal Chemistry Letters. May, 2012 | Pubmed ID: 22483582 LEDGF/p75-independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs PLoS Pathogens. 2012 | Pubmed ID: 22396646 Development of an AlphaScreen-based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors Journal of Biomolecular Screening. Jun, 2012 | Pubmed ID: 22337657 Lens Epithelium-derived Growth Factor/p75 Qualifies As a Target for HIV Gene Therapy in the NSG Mouse Model Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2012 | Pubmed ID: 22334021 Regulator of G-protein Signaling 18 Controls Megakaryopoiesis and the Cilia-mediated Vertebrate Mechanosensory System FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2012 | Pubmed ID: 22308195 The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity Molecular Cancer Research : MCR. Mar, 2012 | Pubmed ID: 22275515 Nitrogen-containing Polyhydroxylated Aromatics As HIV-1 Integrase Inhibitors: Synthesis, Structure-activity Relationship Analysis, and Biological Activity Journal of Enzyme Inhibition and Medicinal Chemistry. Oct, 2012 | Pubmed ID: 22233539 Preclinical Evaluation of [11C]NE40, a Type 2 Cannabinoid Receptor PET Tracer Nuclear Medicine and Biology. Apr, 2012 | Pubmed ID: 22154685 Elvitegravir: a Once Daily Alternative to Raltegravir The Lancet Infectious Diseases. Jan, 2012 | Pubmed ID: 22015078 Pathway Specific Gene Expression Profiling Reveals Oxidative Stress Genes Potentially Regulated by Transcription Co-activator LEDGF/p75 in Prostate Cancer Cells The Prostate. May, 2012 | Pubmed ID: 21796653 Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 21987578 4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic Acid As a Prototype to Develop Dual Inhibitors of HIV-1 Integration Process Antiviral Research. Oct, 2011 | Pubmed ID: 21767569 Rilpivirine: a Step Forward in Tailored HIV Treatment Lancet. Jul, 2011 | Pubmed ID: 21763920 In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75 Journal of Molecular Biology. Jul, 2011 | Pubmed ID: 21763490 Synthesis, in Vitro and in Vivo Evaluation of Fluorine-18 Labelled FE-GW405833 As a PET Tracer for Type 2 Cannabinoid Receptor Imaging Bioorganic & Medicinal Chemistry. Aug, 2011 | Pubmed ID: 21737287 MiR669a and MiR669q Prevent Skeletal Muscle Differentiation in Postnatal Cardiac Progenitors The Journal of Cell Biology. Jun, 2011 | Pubmed ID: 21708977 Toward the Discovery of Novel Anti-HIV Drugs. Second-generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti-HIV Activity: Synthesis, Structure-activity Relationship Analysis, Cytotoxicity Studies, and Target Validation ChemMedChem. Aug, 2011 | Pubmed ID: 21698775 Association of Polymorphisms in the LEDGF/p75 Gene (PSIP1) with Susceptibility to HIV-1 Infection and Disease Progression AIDS (London, England). Sep, 2011 | Pubmed ID: 21681054 A PET Brain Reporter Gene System Based on Type 2 Cannabinoid Receptors Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jul, 2011 | Pubmed ID: 21680683 Comparative Analysis of Different Peptidyl-prolyl Isomerases Reveals FK506-binding Protein 12 As the Most Potent Enhancer of Alpha-synuclein Aggregation The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21652707 Unraveling the Role of Peptidyl-prolyl Isomerases in Neurodegeneration Molecular Neurobiology. Aug, 2011 | Pubmed ID: 21553017 Depletion of PINK1 Affects Mitochondrial Metabolism, Calcium Homeostasis and Energy Maintenance Journal of Cell Science. Apr, 2011 | Pubmed ID: 21385841 Magnesium Chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, As Inhibitors of HIV-1 Integrase And/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function Journal of Medicinal Chemistry. Mar, 2011 | Pubmed ID: 21366258 Interplay Between HIV Entry and Transportin-SR2 Dependency Retrovirology. 2011 | Pubmed ID: 21276267 A Versatile and Practical Synthesis Toward the Development of Novel HIV-1 Integrase Inhibitors ChemMedChem. Feb, 2011 | Pubmed ID: 21246739 HIV-1 Integrase Strand-transfer Inhibitors: Design, Synthesis and Molecular Modeling Investigation European Journal of Medicinal Chemistry. Feb, 2011 | Pubmed ID: 21227550 2-hydroxyisoquinoline-1,3(2H,4H)-diones As Inhibitors of HIV-1 Integrase and Reverse Transcriptase RNase H Domain: Influence of the Alkylation of Position 4 European Journal of Medicinal Chemistry. Feb, 2011 | Pubmed ID: 21185110 The Transcriptional Co-activator LEDGF/p75 Displays a Dynamic Scan-and-lock Mechanism for Chromatin Tethering Nucleic Acids Research. Mar, 2011 | Pubmed ID: 20974633 Small Molecules Targeting the Interaction Between HIV-1 Integrase and LEDGF/p75 Cofactor Bioorganic & Medicinal Chemistry. Nov, 2010 | Pubmed ID: 20850978 Efficient Gene Transfer into the Mouse Lung by Fetal Intratracheal Injection of RAAV2/6.2 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20664525 New Chloro,fluorobenzylindole Derivatives As Integrase Strand-transfer Inhibitors (INSTIs) and Their Mode of Action Bioorganic & Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20630765 New 2-arylnaphthalenediols and Triol Inhibitors of HIV-1 Integrase--discovery of a New Polyhydroxylated Antiviral Agent Bioorganic & Medicinal Chemistry. Jul, 2010 | Pubmed ID: 20541944 Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-associated Viral Vectors at Scale Human Gene Therapy. Oct, 2010 | Pubmed ID: 20497038 High-resolution Profiling of the LEDGF/p75 Chromatin Interaction in the ENCODE Region Nucleic Acids Research. Oct, 2010 | Pubmed ID: 20484370 Rational Design of Small-molecule Inhibitors of the LEDGF/p75-integrase Interaction and HIV Replication Nature Chemical Biology. Jun, 2010 | Pubmed ID: 20473303 Differential Effects of Progenitor Cell Populations on Left Ventricular Remodeling and Myocardial Neovascularization After Myocardial Infarction Journal of the American College of Cardiology. May, 2010 | Pubmed ID: 20466204 LEDGF Hybrids Efficiently Retarget Lentiviral Integration into Heterochromatin Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2010 | Pubmed ID: 20195265 Morphologic and Functional Changes in the Unilateral 6-hydroxydopamine Lesion Rat Model for Parkinson's Disease Discerned with MicroSPECT and Quantitative MRI Magma (New York, N.Y.). Apr, 2010 | Pubmed ID: 20169465 Immunohistochemical Detection of Transgene Expression in the Brain Using Small Epitope Tags BMC Biotechnology. 2010 | Pubmed ID: 20167102 Inhibition of FK506 Binding Proteins Reduces Alpha-synuclein Aggregation and Parkinson's Disease-like Pathology The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2010 | Pubmed ID: 20164329 Fetal Surgery is a Clinical Reality Seminars in Fetal & Neonatal Medicine. Feb, 2010 | Pubmed ID: 19913467 In Search of Second-generation HIV Integrase Inhibitors: Targeting Integration Beyond Strand Transfer Future Medicinal Chemistry. Oct, 2009 | Pubmed ID: 21426102 State-of-the-art Lentiviral Vectors for Research Use: Risk Assessment and Biosafety Recommendations Current Gene Therapy. Dec, 2009 | Pubmed ID: 20021330 Pharmacophore-based Discovery of Small-molecule Inhibitors of Protein-protein Interactions Between HIV-1 Integrase and Cellular Cofactor LEDGF/p75 ChemMedChem. Aug, 2009 | Pubmed ID: 19565598 Seeing Genes at Work in the Living Brain with Non-invasive Molecular Imaging Current Gene Therapy. Jun, 2009 | Pubmed ID: 19519365 Synthesis and Biological Evaluation of (11)C-labeled Beta-galactosyl Triazoles As Potential PET Tracers for in Vivo LacZ Reporter Gene Imaging Bioorganic & Medicinal Chemistry. Jul, 2009 | Pubmed ID: 19515568 Exploration of Novel Thiobarbituric Acid-, Rhodanine- and Thiohydantoin-based HIV-1 Integrase Inhibitors Bioorganic & Medicinal Chemistry Letters. Jul, 2009 | Pubmed ID: 19447621 Highly Efficient Multicistronic Lentiviral Vectors with Peptide 2A Sequences Human Gene Therapy. Aug, 2009 | Pubmed ID: 19419274 Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19244240 Docking Studies on a New Human Immunodeficiency Virus Integrase-Mg-DNA Complex: Phenyl Ring Exploration and Synthesis of 1H-benzylindole Derivatives Through Fluorine Substitutions Journal of Medicinal Chemistry. Jan, 2009 | Pubmed ID: 19105658 In Search of Small Molecules Blocking Interactions Between HIV Proteins and Intracellular Cofactors Molecular BioSystems. Jan, 2009 | Pubmed ID: 19081927 Targeting the HIV Integration Process in Antiviral Therapy Journal of HIV Therapy. Dec, 2008 | Pubmed ID: 19418658 Design, Synthesis, and Biological Evaluation of a Series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones As Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain Journal of Medicinal Chemistry. Dec, 2008 | Pubmed ID: 19053754 Novel Targets for HIV Therapy Antiviral Research. Dec, 2008 | Pubmed ID: 18789977 Transportin-SR2 Imports HIV into the Nucleus Current Biology : CB. Aug, 2008 | Pubmed ID: 18722123 Alternative Splicing and Caspase-mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF/p75 Molecular Cancer Research : MCR. Aug, 2008 | Pubmed ID: 18708362 Synthesis and Antiviral Properties of Some Polyphenols Related to Salvia Genus Bioorganic & Medicinal Chemistry Letters. Aug, 2008 | Pubmed ID: 18674899 Investigations on the 4-quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-activity Relationship of a Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors Journal of Medicinal Chemistry. Aug, 2008 | Pubmed ID: 18665580 Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging Stem Cells (Dayton, Ohio). Sep, 2008 | Pubmed ID: 18599812 Preclinical Evaluation of 1H-benzylindole Derivatives As Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors Antimicrobial Agents and Chemotherapy. Aug, 2008 | Pubmed ID: 18541726 Four-tiered Pi Interaction at the Dimeric Interface of HIV-1 Integrase Critical for DNA Integration and Viral Infectivity Virology. Aug, 2008 | Pubmed ID: 18514248 A Refined Pharmacophore Model for HIV-1 Integrase Inhibitors: Optimization of Potency in the 1H-benzylindole Series Bioorganic & Medicinal Chemistry Letters. May, 2008 | Pubmed ID: 18417342 Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-resistance to the Clinical Trial Drug GS-9137 Antimicrobial Agents and Chemotherapy. Jun, 2008 | Pubmed ID: 18378713 Reaction of Rosmarinic Acid with Nitrite Ions in Acidic Conditions: Discovery of Nitro- and Dinitrorosmarinic Acids As New Anti-HIV-1 Agents Journal of Medicinal Chemistry. Apr, 2008 | Pubmed ID: 18351727 FK506 Binding Protein 12 Differentially Accelerates Fibril Formation of Wild Type Alpha-synuclein and Its Clinical Mutants A30P or A53T Journal of Neurochemistry. Jul, 2008 | Pubmed ID: 18346205 Inhibitory Profile of a LEDGF/p75 Peptide Against HIV-1 Integrase: Insight into Integrase-DNA Complex Formation and Catalysis FEBS Letters. Apr, 2008 | Pubmed ID: 18331842 Quinolone 3-carboxylic Acid Pharmacophore: Design of Second Generation HIV-1 Integrase Inhibitors Journal of Medicinal Chemistry. Mar, 2008 | Pubmed ID: 18281931 The Total Synthesis of Fukiic Acid, an HIV-1 Integrase Inhibitor European Journal of Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18243421 Diffusion of Myelin Oligodendrocyte Glycoprotein in Living OLN-93 Cells Investigated by Raster-scanning Image Correlation Spectroscopy (RICS) Journal of Fluorescence. Sep, 2008 | Pubmed ID: 18204890 Synthesis and Evaluation of 18F- and 11C-labeled Phenyl-galactopyranosides As Potential Probes for in Vivo Visualization of LacZ Gene Expression Using Positron Emission Tomography Bioconjugate Chemistry. Feb, 2008 | Pubmed ID: 18179161 Efficient Purification and Metabolite Analysis of Radiotracers Using High-performance Liquid Chromatography and On-line Solid-phase Extraction Journal of Chromatography. A. May, 2008 | Pubmed ID: 18045609 A P-[18F]fluoroethoxyphenyl Bicyclic Nucleoside Analogue As a Potential Positron Emission Tomography Imaging Agent for Varicella-zoster Virus Thymidine Kinase Gene Expression Journal of Medicinal Chemistry. Dec, 2007 | Pubmed ID: 18047266 Discovery of Novel Non-cytotoxic Salicylhydrazide Containing HIV-1 Integrase Inhibitors Bioorganic & Medicinal Chemistry Letters. Dec, 2007 | Pubmed ID: 17950601 Local Origin and Activity-dependent Generation of Nestin-expressing Protoplasmic Astrocytes in CA1 Brain Structure & Function. Jul, 2007 | Pubmed ID: 17717696 Toward Novel HIV-1 Integrase Binding Inhibitors: Molecular Modeling, Synthesis, and Biological Studies Bioorganic & Medicinal Chemistry Letters. Oct, 2007 | Pubmed ID: 17716893 Differential Interaction of HIV-1 Integrase and JPO2 with the C Terminus of LEDGF/p75 Journal of Molecular Biology. Sep, 2007 | Pubmed ID: 17669426 Novel Virtual Screening Protocol Based on the Combined Use of Molecular Modeling and Electron-ion Interaction Potential Techniques to Design HIV-1 Integrase Inhibitors Journal of Chemical Information and Modeling. Jul-Aug, 2007 | Pubmed ID: 17608406 New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, Beta-diketo Acid Analogs As HIV-1 Integrase Inhibitors Archiv Der Pharmazie. Jun, 2007 | Pubmed ID: 17562561 Lentiviral Nuclear Import: a Complex Interplay Between Virus and Host BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. May, 2007 | Pubmed ID: 17450594 Synthesis and Biological Evaluation of an 123I-labeled Bicyclic Nucleoside Analogue (BCNA) As Potential SPECT Tracer for VZV-tk Reporter Gene Imaging Bioorganic & Medicinal Chemistry Letters. Jun, 2007 | Pubmed ID: 17446073 Fetal Gene Transfer with Lentiviral Vectors: Long-term in Vivo Follow-up Evaluation in a Rat Model American Journal of Obstetrics and Gynecology. Apr, 2007 | Pubmed ID: 17403419 Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV PLoS Pathogens. Mar, 2007 | Pubmed ID: 17397262 Comparative Analysis of Adeno-associated Viral Vector Serotypes 1, 2, 5, 7, and 8 in Mouse Brain Human Gene Therapy. Mar, 2007 | Pubmed ID: 17343566 Synthesis and Preliminary Evaluation of 18F- or 11C-labeled Bicyclic Nucleoside Analogues As Potential Probes for Imaging Varicella-zoster Virus Thymidine Kinase Gene Expression Using Positron Emission Tomography Journal of Medicinal Chemistry. Mar, 2007 | Pubmed ID: 17298046 Simple Criterion for Selection of Flavonoid Compounds with Anti-HIV Activity Bioorganic & Medicinal Chemistry Letters. Mar, 2007 | Pubmed ID: 17189684 Identification of the LEDGF/p75 Binding Site in HIV-1 Integrase Journal of Molecular Biology. Feb, 2007 | Pubmed ID: 17137594 Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis Stem Cells (Dayton, Ohio). Feb, 2007 | Pubmed ID: 17082225 Non-invasive Imaging of Neuropathology in a Rat Model of Alpha-synuclein Overexpression Neurobiology of Aging. Feb, 2007 | Pubmed ID: 16423428 Overexpression of the Lens Epithelium-derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication Journal of Virology. Dec, 2006 | Pubmed ID: 16987986 The Central DNA Flap of the Human Immunodeficiency Virus Type 1 is Important for Viral Replication Biochemical and Biophysical Research Communications. Oct, 2006 | Pubmed ID: 16962998 Parkin Protects Against Neurotoxicity in the 6-hydroxydopamine Rat Model for Parkinson's Disease Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2006 | Pubmed ID: 16914382 Comparison of Lentiviral Vector Titration Methods BMC Biotechnology. 2006 | Pubmed ID: 16836756 Noninvasive Monitoring of Long-term Lentiviral Vector-mediated Gene Expression in Rodent Brain with Bioluminescence Imaging Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2006 | Pubmed ID: 16820324 Lentiviral Vectors Mediate Efficient and Stable Gene Transfer in Adult Neural Stem Cells in Vivo Human Gene Therapy. Jun, 2006 | Pubmed ID: 16776572 Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus Journal of Virology. Feb, 2006 | Pubmed ID: 16439544 The Aggregation of Alpha-synuclein is Stimulated by FK506 Binding Proteins As Shown by Fluorescence Correlation Spectroscopy FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2006 | Pubmed ID: 16410343 Cellular Co-factors of HIV-1 Integration Trends in Biochemical Sciences. Feb, 2006 | Pubmed ID: 16403635 Pharmacophore-based Design of HIV-1 Integrase Strand-transfer Inhibitors Journal of Medicinal Chemistry. Nov, 2005 | Pubmed ID: 16250669 Mutations in Both Env and Gag Genes Are Required for HIV-1 Resistance to the Polysulfonic Dendrimer SPL2923, As Corroborated by Chimeric Virus Technology Antiviral Chemistry & Chemotherapy. 2005 | Pubmed ID: 16130523 Upscaling of Lentiviral Vector Production by Tangential Flow Filtration The Journal of Gene Medicine. Oct, 2005 | Pubmed ID: 15906396 Hematopoietic Stem Cell-based Gene Therapy Against HIV Infection: Promises and Caveats AIDS Reviews. Jan-Mar, 2005 | Pubmed ID: 15875660 HIV-1 Integration: an Interplay Between HIV-1 Integrase, Cellular and Viral Proteins AIDS Reviews. Jan-Mar, 2005 | Pubmed ID: 15875659 Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15855167 Measuring Protein-protein Interactions Inside Living Cells Using Single Color Fluorescence Correlation Spectroscopy. Application to Human Immunodeficiency Virus Type 1 Integrase and LEDGF/p75 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005 | Pubmed ID: 15788449 The Interaction of LEDGF/p75 with Integrase is Lentivirus-specific and Promotes DNA Binding The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15749713 Positional Effects of the Central DNA Flap in HIV-1-derived Lentiviral Vectors Biochemical and Biophysical Research Communications. Mar, 2005 | Pubmed ID: 15707975 Evaluation of the Activity of HIV-1 Integrase Over-expressed in Eukaryotic Cells Biochemical and Biophysical Research Communications. Feb, 2005 | Pubmed ID: 15629457 Multiple Mutations in Human Immunodeficiency Virus-1 Integrase Confer Resistance to the Clinical Trial Drug S-1360 AIDS (London, England). Oct, 2004 | Pubmed ID: 15577623 Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors Journal of Chemical Information and Computer Sciences. Jul-Aug, 2004 | Pubmed ID: 15272853 Identification and Characterization of a Functional Nuclear Localization Signal in the HIV-1 Integrase Interactor LEDGF/p75 The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15163664 Expression of HIV-1 Integrase in CEM Cells Inhibits HIV-1 Replication The Journal of Gene Medicine. Mar, 2004 | Pubmed ID: 15026988 Biosafety of Lentiviral Vectors Current Gene Therapy. Dec, 2003 | Pubmed ID: 14683448 A Short Course on Virology / Vectorology / Gene Therapy Current Gene Therapy. Dec, 2003 | Pubmed ID: 14683447 Lentiviral Vector-mediated Delivery of Short Hairpin RNA Results in Persistent Knockdown of Gene Expression in Mouse Brain Human Gene Therapy. Dec, 2003 | Pubmed ID: 14670130 Development of Resistance Against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations Journal of Virology. Nov, 2003 | Pubmed ID: 14557631 Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vector-mediated Overexpression of Alpha-synuclein Brain Pathology (Zurich, Switzerland). Jul, 2003 | Pubmed ID: 12946025 LEDGF/p75 is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12796494 N-aminoimidazole Derivatives Inhibiting Retroviral Replication Via a Yet Unidentified Mode of Action Journal of Medicinal Chemistry. Apr, 2003 | Pubmed ID: 12672256 Impact of the Central Polypurine Tract on the Kinetics of Human Immunodeficiency Virus Type 1 Vector Transduction Journal of Virology. Apr, 2003 | Pubmed ID: 12663775 Establishment of an in Vitro Assay System Mimicking Human Immunodeficiency Virus Type 1-induced Neural Cell Death and Evaluation of Inhibitors Thereof Journal of Virological Methods. Mar, 2003 | Pubmed ID: 12609687 HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12407101 Env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors Antimicrobial Agents and Chemotherapy. Dec, 2002 | Pubmed ID: 12435701 Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives Antimicrobial Agents and Chemotherapy. Oct, 2002 | Pubmed ID: 12234864 In Search of Authentic Inhibitors of HIV-1 Integration Antiviral Chemistry & Chemotherapy. Jan, 2002 | Pubmed ID: 12180645 New Class of HIV Integrase Inhibitors That Block Viral Replication in Cell Culture Current Biology : CB. Jul, 2002 | Pubmed ID: 12176326 DNA-induced Polymerization of HIV-1 Integrase Analyzed with Fluorescence Fluctuation Spectroscopy The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12147698 Characterization of Lentiviral Vector-mediated Gene Transfer in Adult Mouse Brain Human Gene Therapy. May, 2002 | Pubmed ID: 11975850 Новый хирургический подход к интратрахеального введения биологически активных веществ в фетальный модель мыши Marianne S. Carlon*1, Jaan Toelen*2, Marina Mori da Cunha2, Dragana Vidović1, Anke Van der Perren3, Steffi Mayer2, Lourenço Sbragia2, Johan Nuyts4, Uwe Himmelreich5, Zeger Debyser1, Jan Deprest2 1Molecular Virology and Gene Therapy, KU Leuven, 2Department of Woman and Child, KU Leuven, 3Neurobiology and Gene Therapy, KU Leuven, 4Division of Nuclear Medicine, KU Leuven, 5Biomedical NMR Unit/ MoSAIC, KU Leuven JoVE 4219 Medicine
Новый хирургический подход к интратрахеального введения биологически активных веществ в фетальный модель мыши Marianne S. Carlon*1, Jaan Toelen*2, Marina Mori da Cunha2, Dragana Vidović1, Anke Van der Perren3, Steffi Mayer2, Lourenço Sbragia2, Johan Nuyts4, Uwe Himmelreich5, Zeger Debyser1, Jan Deprest2 1Molecular Virology and Gene Therapy, KU Leuven, 2Department of Woman and Child, KU Leuven, 3Neurobiology and Gene Therapy, KU Leuven, 4Division of Nuclear Medicine, KU Leuven, 5Biomedical NMR Unit/ MoSAIC, KU Leuven JoVE 4219 Medicine
