Zhang Zaijun Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy Jinan University Biography Publications Institution JoVE Articles Zhang Zaijun has not added a biography. If you are Zhang Zaijun and would like to personalize this page please email our Author Liaison for assistance. Publications Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates As Cardioprotective Agents Chemical & Pharmaceutical Bulletin. 2017 | Pubmed ID: 28381679 Neuroprotective and Axonal Outgrowth-promoting Effects of Tetramethylpyrazine Nitrone in Chronic Cerebral Hypoperfusion Rats and Primary Hippocampal Neurons Exposed to Hypoxia Neuropharmacology. May, 2017 | Pubmed ID: 28342896 Tetramethylpyrazine Nitrone Protects Retinal Ganglion Cells Against N-methyl-d-aspartate-induced Excitotoxicity Journal of Neurochemistry. May, 2017 | Pubmed ID: 28160291 Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson's Disease Model Journal of Molecular Neuroscience : MN. Apr, 2017 | Pubmed ID: 28144826 Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia Journal of Proteome Research. Mar, 2017 | Pubmed ID: 28102082 Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine Derivatives As Potential Neuroprotective Agents Chemical & Pharmaceutical Bulletin. Jan, 2017 | Pubmed ID: 27746410 Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis Via Concurrently Inhibiting GSK3β and the ERK Pathway Cellular and Molecular Neurobiology. May, 2017 | Pubmed ID: 27412761 Tetramethylpyrazine Nitrone, a Multifunctional Neuroprotective Agent for Ischemic Stroke Therapy Scientific Reports. Nov, 2016 | Pubmed ID: 27841332 Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury Neurochemical Research. Nov, 2016 | Pubmed ID: 27452038 Neuroprotection Against Glutamate-induced Excitotoxicity and Induction of Neurite Outgrowth by T-006, a Novel Multifunctional Derivative of Tetramethylpyrazine in Neuronal Cell Models Neurochemistry International. Oct, 2016 | Pubmed ID: 27445088 Andrographolide Derivative AL-1 Ameliorates TNBS-induced Colitis in Mice: Involvement of NF-кB and PPAR-γ Signaling Pathways Scientific Reports. Jul, 2016 | Pubmed ID: 27435110 Design, Synthesis and Evaluation of Novel Dual Monoamine-cholinesterase Inhibitors As Potential Treatment for Alzheimer's Disease Neuropharmacology. Oct, 2016 | Pubmed ID: 27318273 Potent Protection Against MPP(+)-Induced Neurotoxicity Via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Neuromolecular Medicine. Dec, 2016 | Pubmed ID: 27277280 Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia Oxyphylla for Use in Parkinson's Disease Through LC/MS-Based Multivariate Data Analysis-Guided Fractionation Journal of Proteome Research. Aug, 2016 | Pubmed ID: 27246451 Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection Via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B Journal of Agricultural and Food Chemistry. Jul, 2016 | Pubmed ID: 27245668 Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice ACS Chemical Neuroscience. Aug, 2016 | Pubmed ID: 27046396 Protective Effects of Andrographolide Derivative AL-1 on High Glucose-induced Oxidative Stress in RIN-m Cells Current Pharmaceutical Design. 2016 | Pubmed ID: 26391852 Protective Effect of Edaravone in Primary Cerebellar Granule Neurons Against Iodoacetic Acid-Induced Cell Injury Oxidative Medicine and Cellular Longevity. 2015 | Pubmed ID: 26557222 Online Coupling of Hydrophilic Interaction/strong Cation Exchange/reversed-phase Liquid Chromatography with Porous Graphitic Carbon Liquid Chromatography for Simultaneous Proteomics and N-glycomics Analysis Journal of Chromatography. A. Oct, 2015 | Pubmed ID: 26362810 Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells Via Activating MEF2D Through the Inhibition of GSK3β Journal of Molecular Neuroscience : MN. Dec, 2015 | Pubmed ID: 26346600 Fully Automated Multidimensional Reversed-phase Liquid Chromatography with Tandem Anion/cation Exchange Columns for Simultaneous Global Endogenous Tyrosine Nitration Detection, Integral Membrane Protein Characterization, and Quantitative Proteomics Mapping in Cerebral Infarcts Analytical Chemistry. Oct, 2015 | Pubmed ID: 26335518 Corrigendum: Novel Anti-thrombotic Agent for Modulation of Protein Disulfide Isomerase Family Member ERp57 for Prophylactic Therapy Scientific Reports. Sep, 2015 | Pubmed ID: 26329261 Novel Anti-thrombotic Agent for Modulation of Protein Disulfide Isomerase Family Member ERp57 for Prophylactic Therapy Scientific Reports. Jun, 2015 | Pubmed ID: 26037049 Relaxation Effect of a Novel Danshensu/tetramethylpyrazine Derivative on Rat Mesenteric Arteries European Journal of Pharmacology. Aug, 2015 | Pubmed ID: 25952729 Examining the Neuroprotective Effects of Protocatechuic Acid and Chrysin on in Vitro and in Vivo Models of Parkinson Disease Free Radical Biology & Medicine. Jul, 2015 | Pubmed ID: 25769424 Andrographolide Derivative AL-1 Improves Insulin Resistance Through Down-regulation of NF-κB Signalling Pathway British Journal of Pharmacology. Jun, 2015 | Pubmed ID: 25712508 Pharmacokinetic and Metabolic Studies of ADTM: A Novel Danshensu Derivative Confers Cardioprotection by HPLC-UV and LC-MS/MS Journal of Chromatographic Science. Jul, 2015 | Pubmed ID: 25609599 A Versatile Reversed Phase-strong Cation Exchange-reversed Phase (RP-SCX-RP) Multidimensional Liquid Chromatography Platform for Qualitative and Quantitative Shotgun Proteomics The Analyst. Feb, 2015 | Pubmed ID: 25554751 Inhibiting β-amyloid-associated Alzheimer's Pathogenesis in Vitro and in Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue Journal of Molecular Neuroscience : MN. Apr, 2015 | Pubmed ID: 25407821 Online Two-dimensional Porous Graphitic Carbon/reversed Phase Liquid Chromatography Platform Applied to Shotgun Proteomics and Glycoproteomics Analytical Chemistry. Dec, 2014 | Pubmed ID: 25393709 Protective Effect of Chinonin in MPTP-induced C57BL/6 Mouse Model of Parkinson's Disease Biological & Pharmaceutical Bulletin. 2014 | Pubmed ID: 24871044 Neuroprotective Effects of the Andrographolide Analogue AL-1 in the MPP⁺/MPTP-induced Parkinson's Disease Model in Vitro and in Mice Pharmacology, Biochemistry, and Behavior. Jul, 2014 | Pubmed ID: 24726706 Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson's Disease in Vitro and in Vivo Biological & Pharmaceutical Bulletin. 2014 | Pubmed ID: 24305623 The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-induced Neurotoxicity Via Inhibition of Mitochondrial-dependent Apoptosis Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2014 | Pubmed ID: 24233519 A Novel Danshensu Derivative Confers Cardioprotection Via PI3K/Akt and Nrf2 Pathways International Journal of Cardiology. Sep, 2013 | Pubmed ID: 23290949 The Anti-cancer Agent SU4312 Unexpectedly Protects Against MPP(+) -induced Neurotoxicity Via Selective and Direct Inhibition of Neuronal NOS British Journal of Pharmacology. Mar, 2013 | Pubmed ID: 23062100 Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene Evidence-based Complementary and Alternative Medicine : ECAM. 2012 | Pubmed ID: 23243436 Unexpected Neuronal Protection of SU5416 Against 1-Methyl-4-phenylpyridinium Ion-induced Toxicity Via Inhibiting Neuronal Nitric Oxide Synthase PloS One. 2012 | Pubmed ID: 23049997 Synthesis and Preliminary Anticancer Evaluation of 10-hydroxycamptothecin Analogs Biological & Pharmaceutical Bulletin. 2012 | Pubmed ID: 22863928 Baicalein Protects Against 6-OHDA-induced Neurotoxicity Through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways Journal of Agricultural and Food Chemistry. Aug, 2012 | Pubmed ID: 22838648 Novel Multi-functional Nitrones for Treatment of Ischemic Stroke Bioorganic & Medicinal Chemistry. Jun, 2012 | Pubmed ID: 22579617 Bis(12)-hupyridone, a Novel Multifunctional Dimer, Promotes Neuronal Differentiation More Potently Than Its Monomeric Natural Analog Huperzine A Possibly Through α7 NAChR Brain Research. Jul, 2011 | Pubmed ID: 21665194 Eriocaulon Buergerianum Extract Protects PC12 Cells and Neurons in Zebrafish Against 6-hydroxydopamine-induced Damage Chinese Medicine. Apr, 2011 | Pubmed ID: 21527031 Synthesis and Biological Evaluations of Novel Apocynin Analogues European Journal of Medicinal Chemistry. Jul, 2011 | Pubmed ID: 21514981 Preventive Effects of Flos Perariae (Gehua) Water Extract and Its Active Ingredient Puerarin in Rodent Alcoholism Models Chinese Medicine. Oct, 2010 | Pubmed ID: 20974012 Hypoglycemic and Beta Cell Protective Effects of Andrographolide Analogue for Diabetes Treatment Journal of Translational Medicine. Jul, 2009 | Pubmed ID: 19607676 Synthesis and Evaluation of Antibacterial Activities of Andrographolide Analogues European Journal of Medicinal Chemistry. Jul, 2009 | Pubmed ID: 19152987 Antioxidative and Thrombolytic TMP Nitrone for Treatment of Ischemic Stroke Bioorganic & Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18790647 Synthesis and Antitumor Activity Evaluations of Albumin-binding Prodrugs of CC-1065 Analog Bioorganic & Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18508273 Synthesis and Preliminary Antitumor Activity Evaluation of a DHA and Doxorubicin Conjugate Bioorganic & Medicinal Chemistry Letters. Jun, 2006 | Pubmed ID: 16563756 小脳顆粒ニューロン培養におけるFluorescein Diacetate-Propidium Iodide二重染色を用いたニューロン生存率の評価 Lin Jiajia*1, Mak Shinghung*2, Zheng Jiacheng1, Wang Jialing1, Xu Dilin1, Hu Shengquan2, Zhang Zaijun3, Wang Qinwen1, Han Yifan2,4, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, 3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, 4International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong JoVE 55442 Neuroscience
小脳顆粒ニューロン培養におけるFluorescein Diacetate-Propidium Iodide二重染色を用いたニューロン生存率の評価 Lin Jiajia*1, Mak Shinghung*2, Zheng Jiacheng1, Wang Jialing1, Xu Dilin1, Hu Shengquan2, Zhang Zaijun3, Wang Qinwen1, Han Yifan2,4, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, 3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, 4International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong JoVE 55442 Neuroscience
