Zoltán Ivics Division of Medical Biotechnology Paul-Ehrlich-Institute Biography Publications Institution JoVE Articles Zoltán Ivics has not added a biography. If you are Zoltán Ivics and would like to personalize this page please email our Author Liaison for assistance. Publications Jumping Ahead with : Mechanistic Insights into Cut-and-Paste Transposition Viruses. Jan, 2021 | Pubmed ID: 33429848 Modeling MyD88 Deficiency Provides New Insights in Its Function Frontiers in Immunology. 2020 | Pubmed ID: 33424861 Intruder (DD38E), a Recently Evolved Sibling Family of DD34E/Tc1 Transposons in Animals Mobile DNA. Dec, 2020 | Pubmed ID: 33303022 ERBB2-CAR-Engineered Cytokine-Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma Frontiers in Immunology. 2020 | Pubmed ID: 33193388 Liver-expressed and Limit Hepatitis C Virus Cross-species Transmission to Mice Science Advances. Nov, 2020 | Pubmed ID: 33148654 Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier Than Ever: Refinement and Recent Innovations of the Sleeping Beauty Transposon System Enabling Novel, Nonviral Genetic Engineering Applications BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 11, 2020 | Pubmed ID: 32939778 Multiple Invasions of Visitor, a DD41D Family of Tc1/mariner Transposons, Throughout the Evolution of Vertebrates Genome Biology and Evolution. Jul, 2020 | Pubmed ID: 32602886 Nuclear Inclusions of Pathogenic Ataxin-1 Induce Oxidative Stress and Perturb the Protein Synthesis Machinery Redox Biology. 05, 2020 | Pubmed ID: 32145456 RNA-guided Retargeting of S Transposition in Human Cells ELife. Mar, 2020 | Pubmed ID: 32142408 Potent CAR-T Cells Engineered with Sleeping Beauty Transposon Vectors Display a Central Memory Phenotype Gene Therapy. Mar, 2020 | Pubmed ID: 32139891 A Single Amino Acid Switch Converts the Sleeping Beauty Transposase into an Efficient Unidirectional Excisionase with Utility in Stem Cell Reprogramming Nucleic Acids Research. 01, 2020 | Pubmed ID: 31777924 , a DD36E Family of Transposons Newly Discovered in Animals Mobile DNA. 2019 | Pubmed ID: 31788035 A Highly Soluble Sleeping Beauty Transposase Improves Control of Gene Insertion Nature Biotechnology. 12, 2019 | Pubmed ID: 31685959 Transcriptionally Promiscuous "blurry" Promoters in Tc1/ Transposons Allow Transcription in Distantly Related Genomes Mobile DNA. 2019 | Pubmed ID: 30988701 Evolution-guided Evaluation of the Inverted Terminal Repeats of the Synthetic Transposon Sleeping Beauty Scientific Reports. 02, 2019 | Pubmed ID: 30718656 Self-assembled Peptide-poloxamine Nanoparticles Enable in Vitro and in Vivo Genome Restoration for Cystic Fibrosis Nature Nanotechnology. 03, 2019 | Pubmed ID: 30692673 Sustained and Regulated Gene Expression by Tet-inducible "all-in-one" Retroviral Vectors Containing the HNRPA2B1-CBX3 UCOE Biomaterials. 02, 2019 | Pubmed ID: 30508767 Author Correction: Isolation and Cultivation of Naive-like Human Pluripotent Stem Cells Based on HERVH Expression Nature Protocols. Aug, 2019 | Pubmed ID: 30374153 Author Correction: Reprogramming Triggers Endogenous L1 and Alu Retrotransposition in Human Induced Pluripotent Stem Cells Nature Communications. 12, 2018 | Pubmed ID: 30568248 Non-viral Therapeutic Cell Engineering with the Sleeping Beauty Transposon System Current Opinion in Genetics & Development. 10, 2018 | Pubmed ID: 29957586 Efficient Non-viral Gene Delivery into Human Hematopoietic Stem Cells by Minicircle Sleeping Beauty Transposon Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. 04, 2018 | Pubmed ID: 29503198 Evaluating Different DNA Binding Domains to Modulate L1 ORF2p-driven Site-specific Retrotransposition Events in Human Cells Gene. Feb, 2018 | Pubmed ID: 29154869 Alterations in SCAI Expression During Cell Plasticity, Fibrosis and Cancer Pathology Oncology Research : POR. Jul, 2018 | Pubmed ID: 28815470 Modulation of the Functional Association Between the HIV-1 Intasome and the Nucleosome by Histone Amino-terminal Tails Retrovirology. Nov, 2017 | Pubmed ID: 29179726 Gene Therapy with the Sleeping Beauty Transposon System Trends in Genetics : TIG. 11, 2017 | Pubmed ID: 28964527 Generation of an Immortalized Mesenchymal Stem Cell Line Producing a Secreted Biosensor Protein for Glucose Monitoring PloS One. 2017 | Pubmed ID: 28949988 Transposons As Tools for Functional Genomics in Vertebrate Models Trends in Genetics : TIG. 11, 2017 | Pubmed ID: 28888423 Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System Human Gene Therapy. 10, 2017 | Pubmed ID: 28870121 The Piwi-piRNA Pathway: Road to Immortality Aging Cell. 10, 2017 | Pubmed ID: 28653810 Going Non-viral: the Sleeping Beauty Transposon System Breaks on Through to the Clinical Side Critical Reviews in Biochemistry and Molecular Biology. 08, 2017 | Pubmed ID: 28402189 Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by PFAR4 Plasmids Molecular Therapy. Nucleic Acids. Mar, 2017 | Pubmed ID: 28325297 Transposition of the Bamboo Mariner-like Element Ppmar1 in Yeast Molecular Phylogenetics and Evolution. 04, 2017 | Pubmed ID: 28189615 Regulated Complex Assembly Safeguards the Fidelity of Sleeping Beauty Transposition Nucleic Acids Research. Jan, 2017 | Pubmed ID: 27913727 Sleeping Beauty Transposition: from Biology to Applications Critical Reviews in Biochemistry and Molecular Biology. Feb, 2017 | Pubmed ID: 27696897 Minicircle-Based Engineering of Chimeric Antigen Receptor (CAR) T Cells Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 2016 | Pubmed ID: 28101686 Structural Determinants of Sleeping Beauty Transposase Activity Molecular Therapy : the Journal of the American Society of Gene Therapy. 08, 2016 | Pubmed ID: 27401040 Endogenous Transposase Source in Human Cells Mobilizes PiggyBac Transposons Molecular Therapy : the Journal of the American Society of Gene Therapy. 05, 2016 | Pubmed ID: 27198853 Expression of Active Fluorophore Proteins in the Milk of Transgenic Pigs Bypassing the Secretory Pathway Scientific Reports. Apr, 2016 | Pubmed ID: 27086548 Sleeping Beauty Transposase Structure Allows Rational Design of Hyperactive Variants for Genetic Engineering Nature Communications. Mar, 2016 | Pubmed ID: 27025571 A Helitron Transposon Reconstructed from Bats Reveals a Novel Mechanism of Genome Shuffling in Eukaryotes Nature Communications. Mar, 2016 | Pubmed ID: 26931494 One-step Multiplex Transgenesis Via Sleeping Beauty Transposition in Cattle Scientific Reports. Feb, 2016 | Pubmed ID: 26905416 Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells with Sleeping Beauty Transposon-Based Stable Gene Delivery Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26895068 Establishment of Cell-based Transposon-mediated Transgenesis in Cattle Theriogenology. Apr, 2016 | Pubmed ID: 26838464 Isolation and Cultivation of Naive-like Human Pluripotent Stem Cells Based on HERVH Expression Nature Protocols. Feb, 2016 | Pubmed ID: 26797457 Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the PiggyBac Transposon in Primary Human CD4(+) T Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2016 | Pubmed ID: 26755332 Reprogramming Triggers Endogenous L1 and Alu Retrotransposition in Human Induced Pluripotent Stem Cells Nature Communications. Jan, 2016 | Pubmed ID: 26743714 Cytoplasmic Injection of Murine Zygotes with Sleeping Beauty Transposon Plasmids and Minicircles Results in the Efficient Generation of Germline Transgenic Mice Biotechnology Journal. Jan, 2016 | Pubmed ID: 26470758 Self-Destruct Genetic Switch to Safeguard IPS Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2015 | Pubmed ID: 26321184 Sleeping Beauty Transposition Microbiology Spectrum. Apr, 2015 | Pubmed ID: 26104705 Retrotransposition Creates Sloping Shores: a Graded Influence of Hypomethylated CpG Islands on Flanking CpG Sites Genome Research. Aug, 2015 | Pubmed ID: 25995269 Genomic Analysis of Sleeping Beauty Transposon Integration in Human Somatic Cells PloS One. 2014 | Pubmed ID: 25390293 Primate-specific Endogenous Retrovirus-driven Transcription Defines Naive-like Stem Cells Nature. Dec, 2014 | Pubmed ID: 25317556 Excision Efficiency is Not Strongly Coupled to Transgenic Rate: Cell Type-dependent Transposition Efficiency of Sleeping Beauty and PiggyBac DNA Transposons Human Gene Therapy Methods. Aug, 2014 | Pubmed ID: 25045962 Non-viral Reprogramming of Fibroblasts into Induced Pluripotent Stem Cells by Sleeping Beauty and PiggyBac Transposons Biochemical and Biophysical Research Communications. Jul, 2014 | Pubmed ID: 24928388 Assessment of Fetal Cell Chimerism in Transgenic Pig Lines Generated by Sleeping Beauty Transposition PloS One. 2014 | Pubmed ID: 24811124 Germline Transgenesis in Pigs by Cytoplasmic Microinjection of Sleeping Beauty Transposons Nature Protocols. Apr, 2014 | Pubmed ID: 24625780 Germline Transgenesis in Rabbits by Pronuclear Microinjection of Sleeping Beauty Transposons Nature Protocols. Apr, 2014 | Pubmed ID: 24625779 Germline Transgenesis in Rodents by Pronuclear Microinjection of Sleeping Beauty Transposons Nature Protocols. Apr, 2014 | Pubmed ID: 24625778 Suicidal Autointegration of Sleeping Beauty and PiggyBac Transposons in Eukaryotic Cells PLoS Genetics. Mar, 2014 | Pubmed ID: 24625543 Functional Characterization of the Bari1 Transposition System PloS One. 2013 | Pubmed ID: 24244492 Integration Profile and Safety of an Adenovirus Hybrid-vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration PloS One. 2013 | Pubmed ID: 24124483 Regulation of DNA Transposition by CpG Methylation and Chromatin Structure in Human Cells Mobile DNA. May, 2013 | Pubmed ID: 23676100 Cell Division Promotes Efficient Retrotransposition in a Stable L1 Reporter Cell Line Mobile DNA. 2013 | Pubmed ID: 23497436 Sleeping Beauty Transposon-based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells Nucleic Acids Research. Feb, 2013 | Pubmed ID: 23275558 Transposon-mediated Transgenesis, Transgenic Rescue, and Tissue-specific Gene Expression in Rodents and Rabbits FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2013 | Pubmed ID: 23195032 Assessment of Fecundity and Germ Line Transmission in Two Transgenic Pig Lines Produced by Sleeping Beauty Transposition Genes. Oct, 2012 | Pubmed ID: 24705079 Retargeting Sleeping Beauty Transposon Insertions by Engineered Zinc Finger DNA-binding Domains Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2012 | Pubmed ID: 22776959 Retargeting Transposon Insertions by the Adeno-associated Virus Rep Protein Nucleic Acids Research. Aug, 2012 | Pubmed ID: 22523082 The Sleeping Beauty Transposon System for Clinical Applications Expert Opinion on Biological Therapy. Feb, 2012 | Pubmed ID: 22176302 The Antibiotic-free PFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells Molecular Therapy. Nucleic Acids. | Pubmed ID: 29858090 Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells After Sleeping Beauty Transposon-Mediated Gene Delivery Molecular Therapy. Nucleic Acids. | Pubmed ID: 29246287 Uyuyan Güzel Transpozon Sistemi Kullanılarak Primer İnsan Pigment Epitel Hücrelerinin Elektroporasyon Tabanlı Genetik Modifikasyonu Sandra Johnen1, Nina Harmening2,3, Corinne Marie4,5, Daniel Scherman4, Zsuzsanna Izsvák6, Zoltán Ivics7, Peter Walter1, Gabriele Thumann2,3 1Department of Ophthalmology, University Hospital RWTH Aachen, 2Experimental Ophthalmology, University of Geneva, 3Department of Ophthalmology, University Hospitals of Geneva, 4Université de Paris, CNRS, INSERM, UTCBS, Unité des technologies Chimiques et Biologiques pour la Santé, 5Chimie ParisTech, PSL Research University, 6Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 7Division of Medical Biotechnology, Paul-Ehrlich-Institute JoVE 61987 Medicine
Uyuyan Güzel Transpozon Sistemi Kullanılarak Primer İnsan Pigment Epitel Hücrelerinin Elektroporasyon Tabanlı Genetik Modifikasyonu Sandra Johnen1, Nina Harmening2,3, Corinne Marie4,5, Daniel Scherman4, Zsuzsanna Izsvák6, Zoltán Ivics7, Peter Walter1, Gabriele Thumann2,3 1Department of Ophthalmology, University Hospital RWTH Aachen, 2Experimental Ophthalmology, University of Geneva, 3Department of Ophthalmology, University Hospitals of Geneva, 4Université de Paris, CNRS, INSERM, UTCBS, Unité des technologies Chimiques et Biologiques pour la Santé, 5Chimie ParisTech, PSL Research University, 6Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 7Division of Medical Biotechnology, Paul-Ehrlich-Institute JoVE 61987 Medicine
