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Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

August 18th, 2023
1, 1, 2, 2, 2,3, 1,2,3, 1,3,4, 1,3,4
1Cell and Gene Therapy Laboratory, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, 2Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, 3Perelman School of Medicine at the University of Pennsylvania, 4Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia

Summary
Automatic Translation

Denne artikel beskriver fremstillingsprocessen for kimære antigenreceptor T-celler til klinisk brug, specifikt ved hjælp af en automatiseret celleprocessor, der er i stand til at udføre viral transduktion og dyrkning af T-celler. Vi giver anbefalinger og beskriver faldgruber, der bør overvejes under procesudvikling og implementering af et tidligt fase klinisk forsøg.

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