Isolation and Characterization of Bone Marrow Microenvironment in Myeloid Neoplasms

November 10th, 2023

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Christina M. Kaszuba^1,2, Benjamin J. Rodems^1,3, Sonali Sharma^1,3, Edgardo I. Franco^1,2, John M. Ashton^1,3,4, Laura M. Calvi^1,5, Jeevisha Bajaj^1,3

¹Wilmot Cancer Institute, University of Rochester Medical Center, ²Department of Biomedical Engineering, University of Rochester, ³Department of Biomedical Genetics, University of Rochester Medical Center, ⁴Genomics Research Center, University of Rochester Medical Center, ⁵Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center

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هنا يتم تقديم بروتوكول مفصل لعزل وتوصيف مجموعات البيئة الدقيقة لنخاع العظم من نماذج الفئران لمتلازمات خلل التنسج النقوي وسرطان الدم النخاعي الحاد. تحدد هذه التقنية التغيرات في مكانة نخاع العظم غير المكونة للدم ، بما في ذلك الخلايا اللحمية البطانية واللحمة المتوسطة ، مع تطور المرض.

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Isolation and Characterization of Bone Marrow Microenvironment in Myeloid Neoplasms

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