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A Protocol for Computer-Based Protein Structure and Function Prediction

Article DOI: 10.3791/3259-v • 16:41 min • November 3rd, 2011
November 3rd, 2011 •
1,2, 1, 1, 1,2
1Center for Computational Medicine and Bioinformatics, University of Michigan, 2Center for Bioinformatics and Department of Molecular Bioscience, University of Kansas

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Guidelines for computer based structural and functional characterization of protein using the I-TASSER pipeline is described. Starting from query protein sequence, 3D models are generated using multiple threading alignments and iterative structural assembly simulations. Functional inferences are thereafter drawn based on matches to proteins with known structure and functions.

Tags

Protocol Computer-based Protein Structure Function Prediction Genome Sequencing Projects Protein Sequence Structure And Function Knowledge Experimental Methods Computational Modeling I-TASSER Server Secondary Structure Prediction Solvent Accessibility Prediction Homologous Template Proteins Structure Alignments Tertiary Structural Models Structure-based Functional Annotations Confidence Score End Users User-specified Inter-residue Distance Contact Maps I-TASSER Modeling Template Proteins Structure Assembly Simulations
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