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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
JoVE 杂志
生物工程
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JoVE 杂志 生物工程
Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
DOI:

08:52 min

January 10, 2018

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Chapters

  • 00:05Title
  • 01:03Agarose Hydrogel Micro-Column Fabrication
  • 03:51ECM Core Fabrication
  • 05:26Seeding Micro-columns with Astrocytes
  • 06:32Results: Formation of Astrocyte Bundles within Hydrogel Micro-columns over Time
  • 07:54Conclusion

Summary

自动翻译

We showcase the development of self-assembled, three-dimensional bundles of longitudinally aligned astrocytic somata and processes within a novel biomaterial encasement. These engineered "living scaffolds", exhibiting micron-scale diameter yet extending centimeters in length, may serve as test-beds to study neurodevelopmental mechanisms or facilitate neuroregeneration by directing neuronal migration and/or axonal pathfinding.

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