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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Article DOI: 10.3791/55848-v • 08:56 min • January 10th, 2018
January 10th, 2018 •
*1,2,3, *1,2,4, 1,2,4, 1,2, 1,5, 1,5, 1,2,4, 1,2,5
1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 2Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 3School of Biomedical Engineering, Drexel University, 4Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, 5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania
* These authors contributed equally

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We showcase the development of self-assembled, three-dimensional bundles of longitudinally aligned astrocytic somata and processes within a novel biomaterial encasement. These engineered "living scaffolds", exhibiting micron-scale diameter yet extending centimeters in length, may serve as test-beds to study neurodevelopmental mechanisms or facilitate neuroregeneration by directing neuronal migration and/or axonal pathfinding.

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks Developmental Mechanisms Nervous System Regeneration Fabrication Self-assembled Hydrogel Micro-column In Vitro Neuro-biological Model Neuro-regenerative Therapy Trauma Neurodegenerative Disease Neurogenic Capacity Inhibitory Environment Astrocytic Bundles Treatment Strategies Neuroanatomical Features Glia-mediated Developmental Mechanisms Cell Migration Axon Pathfinding Architecture Astrocytic Scaffolds Glial Tubes Rostral Migratory Stream Agarose Solution DPBS Sterile Beaker Heating And Stirring Acupuncture Needle
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