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MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
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MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

Article DOI: 10.3791/3555-v • 07:43 min • March 13th, 2012
March 13th, 2012 •
1, 1,2, 1,2, 1,3
1Imaging Research, Sunnybrook Research Institute, 2Department of Medical Biophysics, University of Toronto, 3Department of Medical Biophysics, and Institute of Biomaterials & Biomedical Engineering (IBBME), University of Toronto

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Summary
Automatic Translation

Microbubble-mediated focused ultrasound disruption of the blood-brain barrier (BBB) is a promising technique for non-invasive targeted drug delivery in the brain1-3. This protocol outlines the experimental procedure for MRI-guided transcranial BBB disruption in a rat model.

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MRI-guided Disruption Blood-brain Barrier Transcranial Focused Ultrasound Rat Model FUS Pharmaceutical Treatments Brain Disorders Molecules Vasculature Size Temporary Reversible Chemical Means Localized Therapeutic Agents Concentration Ultrasound Parameters Experimental Procedure Accurate Targeting Animal Preparation Microbubble Handling
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