Journal
/
Chemie
/
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
JoVE Journal
Chemie
Zum Anzeigen dieser Inhalte ist ein JoVE-Abonnement erforderlich.  Melden Sie sich an oder starten Sie Ihre kostenlose Testversion.
JoVE Journal Chemie
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

DOI:
10.3791/51299-v

•

13:37 min

•

June 20, 2014

•

,
1Scripps Florida,The Scripps Research Institute

Kapitel

  • 00:05Titel
  • 01:43Preparation of Acid Bromide from Natural Amino Acids and Isotopic Labeling of Alanine Using Transaminase
  • 04:39Synthesis of Peptoid Linker Region
  • 06:15Split-and-pool Synthesis of PTA Library with (R)- and (S)-2-bromopropionic Acids
  • 11:10Results: Characterization of a One-Bead-One-Compound Peptide Tertiary Amine Library
  • 13:00Conclusion

Summary

Automatische Übersetzung

Automatische Übersetzung

Peptide tertiary amides (PTAs) are a superfamily of peptidomimetics that include but are not limited to peptides, peptoids and N-methylated peptides. Here we describe a synthetic method which combines both split-and-pool and sub-monomer strategies to synthesize a one-bead one-compound library of PTAs.

Tags

Peptide Tertiary AmidesPeptidomimeticsPeptoidsProtein LigandsSplit-and-pool SynthesisCombinatorial ChemistryOne-bead One-compound LibraryConformational Constraints

Article

Embed

ZUR WIEDERGABELISTE HINZUFÜGEN

Usage Statistics

Verwandte Videos

Nucleoside Triphosphates – From Synthesis to Biochemical Characterization

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Synthesis and Characterization of Functionalized Metal-organic Frameworks

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Synthesis and Characterization of Supramolecular Colloids

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Synthesis and Characterization of Fe-doped Aluminosilicate Nanotubes with Enhanced Electron Conductive Properties

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Read Article