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Venstre lunge ortopisk transplantation i en ung svin model for ESLP

Article DOI: 10.3791/62979-v • 06:55 min • February 14th, 2022
February 14th, 2022 •
1,2, 3, 4, 1,2, 4, 4, 4, 4, 5, 5, 5, 1,2,6,7, 1,2,6,7
1Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine, University of Alberta, 2Mazankowski Alberta Heart Institute, 3Faculty of Medicine and Dentistry, University of Alberta, 4Department of Surgery, Faculty of Medicine, University of Alberta, 5Ray Rajotte Surgical-Medical Research Institute (SMRI), University of Alberta, 6Alberta Transplant Institute, 7Canadian Donation and Transplantation Research Program

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Denne protokol beskriver en ung svinemodel af ortopisk venstre lungeallotransplantation designet til brug med ESLP-forskning. Der fokuseres på anæstetiske og kirurgiske teknikker samt kritiske trin og fejlfinding.

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Venstre lunge ortopisk transplantation Juvenil svinemodel ESLP lungesygdom i slutstadiet lungetransplantation mangel på donororganer ventelistedødelighed ex situ lungeperfusion donorlungeudnyttelsesrater donordonor in vitro-forskningsresultater anatomiske og fysiologiske forskelle tekniske og anæstetiske udfordringer transplantationsmodelvalidering præklinisk evaluering forbedring af donorlungefunktion svinemodel af ortopisk venstre lungeallotransplantation Anæstetiske teknikker kirurgiske teknikker
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