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Journal / Bioengineering / Perfusable Vascular Network with a Tissue Model…
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Bioengineering

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JoVE Journal Bioengineering
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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

Article DOI: 10.3791/57242-v • 07:05 min • April 4th, 2018
April 4th, 2018 •
1, 1, 1, 2, 3, 3, 1, 3, 2, 1
1Department of Micro Engineering, Kyoto University, 2Graduate School of Medical Sciences, Kyushu University, 3International Research Center for Medical Sciences (IRCMS), Kumamoto University

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The protocol describes how to engineer a perfusable vascular network in a spheroid. The spheroid's surrounding microenvironment is devised to induce angiogenesis and connect the spheroid to the microchannels in a microfluidic device. The method allows the perfusion of the spheroid, which is a long-awaited technique in three-dimensional cultures.

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Perfusable Vascular Network Tissue Model Microfluidic Device Multicellular Aggregate Spheroid Regenerative Medicine Drug Delivery Supplement Administration PDMS Prepolymer Vacuum Chamber Curing Silicon Wafer Hole Punch Adhesive Tape Air Plasma Bonding Seeding Microfluidic Device
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