2 articles published in JoVE
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents Maria Vähätupa1,2, Niina Jääskeläinen2, Marc Cerrada-Gimenez2, Rubina Thapa2, Tero Järvinen1, Giedrius Kalesnykas2, Hannele Uusitalo-Järvinen1,3 1Faculty of Medicine and Health Technology, Tampere University & Tampere University Hospital, 2Experimentica Ltd, 3Eye Centre, Tampere University Hospital Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA) Maria Vähätupa*1, Toini Pemmari*1, Ilkka Junttila1,2, Marko Pesu1,2, Tero A.H. Järvinen1 1Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 2Department of Clinical Microbiology, Fimlab Laboratories Two-stage skin carcinogenesis is induced by two topically applied chemicals. A mutagen 7,12-dimethylbenz[a]anthracene) causes mutations in the epidermal cells and a continuous application of general growth stimulator 12-O-tetradecanoyl phorbol-13-acetate accelerates skin papilloma formation.