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Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury

Article DOI: 10.3791/3116-v • 10:26 min • August 30th, 2011
August 30th, 2011 •
1, 2, 1, 1, 1
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Sciences University, 2Department of Pharmacology, University of Colorado Denver

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A powerful model for perioperative and critical care related acute kidney injury is presented. Using whole body hypoperfusion induced by cardiac arrest it is possible to nearly replicate the histologic and functional changes of clinical AKI.

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Normothermic Cardiac Arrest Cardiopulmonary Resuscitation Mouse Model Ischemia-reperfusion Injury Acute Kidney Injury Critical Illness Whole-body Hypoperfusion Rodent Models Focal Ischemia Genetic Manipulation Cardiac Arrest And Cardiopulmonary Resuscitation Model Physiologic Outcomes Functional Outcomes Anatomic Outcomes Histologic Outcomes Murine Surgical Model Organ-specific Outcomes
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