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The ChroP Approach Combines ChIP and Mass Spectrometry to Dissect Locus-specific Proteomic Landscapes of Chromatin

Article DOI: 10.3791/51220-v • 24:02 min • April 11th, 2014
April 11th, 2014 •
1, 1
1Department of Experimental Oncology, European Institute of Oncology

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By combining native and crosslinking chromatin immunoprecipitation with high-resolution Mass Spectrometry, ChroP approach enables to dissect the composite proteomic architecture of histone modifications, variants and non-histonic proteins synergizing at functionally distinct chromatin domains.

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ChroP Approach ChIP Mass Spectrometry Nucleoprotein Complex DNA Proteins Chromatin Structure Histone Post-translational Modifications HPTMs Chromatin-binding Proteins Transcription Factors DNA Methylation Chromatin Proteomics Strategy Chromatin Immunoprecipitation Heterochromatic Regions Lysine 9 Tri-methylation Histone H3 Heterochromatin Proteome Protein Determinants Protein Interactions
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