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Translasjonelle ortotopiske modeller av glioblastom multiforme
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Translasjonelle ortotopiske modeller av glioblastom multiforme

Article DOI: 10.3791/64482-v • 07:37 min • February 17th, 2023
February 17th, 2023 •
1, 1, 1
1Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute

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Her beskriver vi en preklinisk ortotopisk musemodell for GBM, etablert ved intrakraniell injeksjon av celler avledet fra genetisk konstruerte musemodelltumorer. Denne modellen viser sykdomskjennetegnene til human GBM. For translasjonsstudier spores musens hjernesvulst av in vivo MR og histopatologi.

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