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Immunology and Infection

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Un modelo murino avanzado para esteatohepatitis no alcohólica en asociación con diabetes tipo 2
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Un modelo murino avanzado para esteatohepatitis no alcohólica en asociación con diabetes tipo 2

Article DOI: 10.3791/59470-v • 10:17 min • April 26th, 2019
April 26th, 2019 •
1,2,3,4, 3,6, 3,5, 3,5, *1,2,4, *2,3,5
1Department of Endocrinology & Metabolism Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 2Berlin Institute of Health (BIH), 3Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 4DZHK (German Centre for Cardiovascular Research), 5Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 6Julius Wolff Institute (JWI) and Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
* These authors contributed equally

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Se describe un modelo animal simple y confiable para la esteatohepatitis no alcohólica inducida por la dieta, que se logra a través de la carcasa no SPF de los animales y la administración de una dieta alta en grasas específica. Describimos la identificación de los subconjuntos de células inmunes hepáticas y adiposas para recapitular las condiciones inmunológicas humanas exponiendo ratones a gérmenes ambientales.

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Inmunología e infección problema 146 Inmunología y exposición medioambiental obesidad Inmunología adaptable resistencia a la insulina condiciones de la vivienda fenotipos metabólicos citometría de flujo
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