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Improved Visualization and Quantitative Analysis of Drug Effects Using Micropatterned Cells

Article DOI: 10.3791/2514-v • 15:41 min • December 2nd, 2010
December 2nd, 2010 •
1, 1, 1, 2, 1, 1, 1, 1, 1, 1
1CYTOO Cell Architects, Grenoble, France, 2Centre Commun de Quantimétrie, Faculté de Médecine Rockefeller, Lyon, France

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Adhesive micropatterns that normalize cellular architecture can be used to increase sensitivity in the detection of drug effects, improve reproducibility and simplify automated image acquisition and analysis. Such technology will benefit drug/siRNA screening assays, performed on conventional cell culture supports and consequently suffering from excessive cell-to-cell variability.

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Visualization Quantitative Analysis Drug Effects Micropatterned Cells HCA (High Content Analysis) Adherent Cell Lines Homogenous Substrate Cell Shape Morphology Behavior Cell-to-cell Variance Micropatterns Shape Normalization Internal Polarity CYTOO Micropatterning Technology Cell Seeding Drug Treatment Fixation And Staining Automated Acquisition Automated Image Processing Data Analysis Cell Cytoskeleton Actin Meshwork
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