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Chapitre 10
Expression génique spécifique de la cellule
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same…
La régulation de l'expression se produit à plusieurs étapes
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves…
Séquences Cis-régulatrices
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These…
Liaison coopérative des régulateurs de transcription
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences…
Activateurs et répresseurs transcriptionnels procaryotiques
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the…
Opérons
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related…
La région du promoteur chez les eucaryotes
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start…
Co-activateurs et co-répresseurs
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in…
Activateurs de transcription chez les eucaryotes
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate…
Inhibiteurs de transcription chez les eucaryotes
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding…
Contrôle génétique combinatoire
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of…
Cellules souches pluripotentes induites
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific…
Les facteurs de transcription
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often…
Régulation épigénétique
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases…
Empreinte génomique et hérédité
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both…
Identifying Transcription Factor Olig2 Genomic Binding Sites in Acutely Purified PDGFRα+ Cells by Low-cell Chromatin Immunoprecipitation Sequencing Analysis
In mammalian cells, gene transcription is regulated in a cell type specific manner by the interactions of transcriptional factors with genomic DNA.…
A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
As genomes of a wider variety of animals become available, there is an increasing need for tools that can capture dynamic epigenetic changes in these…
Cell Type-specific Gene Expression Profiling in the Mouse Liver
Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental…

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