Trial Ending in: Request Full Access Tell Your Colleague About Jove
Chapter 12

Classical and Modern Genetics

Genetic Lingo
Overview An organism is diploid if it inherits two variants, or alleles, of each gene, one from each parent. These two alleles constitute the…
Punnett Squares
Overview A Punnett square displays the possible genotypes offspring can inherit from two parental genotypes. If a trait’s inheritance pattern…
Monohybrid Crosses
Overview In the 1850s and 1860s, Gregor Mendel investigated inheritance by performing monohybrid crosses in pea plants. He crossed two plants that…
Dihybrid Crosses
Overview To determine whether traits are inherited together or separately, Gregor Mendel crossed pea plants that differed in two traits. These…
Pedigree Analysis
Overview A pedigree is a diagram displaying a family’s history of a trait. Analyzing pedigrees can reveal (1) whether a trait is dominant or…
Probability Laws
Overview The probability of inheriting a trait can be calculated using the sum and product rules. The sum rule is used to calculate the probability…
Multiple Allele Traits
The Concept of Multiple Allelism Multiple allelism describes genes that exist in three or more allelic forms. Although diploid organisms, like…
Polygenic Traits
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have…
Epistasis
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence…
Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene…
Nature and Nurture
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For…
High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in <em>Chlamydomonas reinhardtii</em>
Systematic identification and characterization of genetic perturbations have proven useful to decipher gene function and cellular pathways. However,…
Optogenetic Random Mutagenesis Using Histone-miniSOG in <em>C. elegans</em>
Forward genetic screening in model organisms is the workhorse to discover functionally important genes and pathways in many biological processes. In…
Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Comprehensive genomic analysis has uncovered surprisingly large numbers of genetic alterations in various types of cancers. To robustly and…

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
simple hit counter