The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008

Roger Y. Tsien

doi:10.3791/1575

Editorial

The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008

Published: January 13, 2010 doi: 10.3791/1575

Roger Y. Tsien

Summary

American biochemist Roger Tsien shared the 2008 Nobel Prize in Chemistry with Martin Chalfie and Osamu Shimomura for their discovery and development of the Green Fluorescent Protein (GFP). Tsien dramatically improved the wild-type GFP resulting in increased fluorescence, increased photostability, and a shift in the major excitation peak to 488 nm (matching FITC).

References

Roger Y. Tsien - Autobiography [Internet]. , The Nobel Foundation. Available from: http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/tsien-autobio.html (c2003).
Nobel Lecture by Roger Y. Tsien- Media Player [Internet]. , The Nobel Foundation. Available from: http://nobelprize.org/mediaplayer/index.php?id=1070 (c2003).
Davenport, D., Nicol, J. A. C. Luminescence of hydromedusae. Proc. R. Soc. 144, 399-411 (1955).
Shimomura, O., Johnson, F. H., Saiga, Y. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan. Aequorea. J. Cell. Comp. Physiol. 59, 223-229 (1962).
Tsien, R. Y. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 19 (11), 2396-2404 (1980).
Heim, R., Cubitt, A., Tsien, R. Y. Improved green fluorescence. Nature. 373, 663-664 (1995).

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Roger Y. Tsien Lindau Nobel Laureate Meeting 2008 Nobel Prize In Chemistry Martin Chalfie Osamu Shimomura Green Fluorescent Protein (GFP) Biochemist New York Livingston New Jersey Chemistry Colors Silica Gardens Crystallized Metal Salts Synthesizing Aspirin Laboratory Experience Infrared Spectroscopy Metals Binding To Thiocyanate Scholarship Westinghouse Science Talent Search Harvard Cambridge University Marshall Scholarship Organic Chemistry Dyes For Imaging Neuronal Activity BAPTA Based Optical Calcium Indicator Dyes Postdoctoral Training University Of California Berkeley

[1] Roger Y. Tsien - Autobiography [Internet]. , The Nobel Foundation. Available from: http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/tsien-autobio.html (c2003).

[2] Nobel Lecture by Roger Y. Tsien- Media Player [Internet]. , The Nobel Foundation. Available from: http://nobelprize.org/mediaplayer/index.php?id=1070 (c2003).

[3] Davenport, D., Nicol, J. A. C. Luminescence of hydromedusae. Proc. R. Soc. 144, 399-411 (1955).

[4] Shimomura, O., Johnson, F. H., Saiga, Y. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan. Aequorea. J. Cell. Comp. Physiol. 59, 223-229 (1962).

[5] Tsien, R. Y. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 19 (11), 2396-2404 (1980).

[6] Heim, R., Cubitt, A., Tsien, R. Y. Improved green fluorescence. Nature. 373, 663-664 (1995).

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