İlaç tedavisinden sonra hepatosellüler karsinom organoidlerinin oluşumu ve tek hücreli transkriptomik analizi

497 görüntülenme

08:18 dk.

26 Mayıs 2026

497 görüntülenme

Dan He^*¹ , Zhong Liang^*¹^,²^,³ , Cheng-Yang Zhang^*¹^,²^,³ , Jie-Shen Xian^*⁴ , Yuan-Xiang Yang⁵ , Yuan-Feng Gong³ , Hui Tang³ , Guang-Ding Zhou¹^,²^,³ , Chen-Yu Jiang¹^,²^,³ , Le Xing¹^,²^,³ , Dong-Mei Li¹^,²^,³ , Ying-Chen Hou¹^,²^,³ , Chen Yue¹^,²^,³ , Wei Cheng¹^,² , Yun-Qiang Tang³ , Ming Liu¹^,²^,³ , Xiao-Feng Zhang¹^,²^,³^,⁶

¹School of Basic Medical Science, Guangzhou Medical University, ²Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, ³Affiliated Cancer Hospital and Institute, Guangzhou Medical University, ⁴The First Clinical School of Guangzhou Medical University, Guangzhou Medical University, ⁵Department of Obstetrics, Guangzhou Eighth People's Hospital, Guangzhou Medical University, ⁶Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University

^* These authors contributed equally

Bu protokol, hepatosellüler karsinom organoidlerinin üretilmesi, ilaç tedavisi uygulanması ve tedavi öncesi ve sonrası tek hücreli RNA dizilenmesi için uygulanan sade bir yöntemi ortaya koyarak tedaviyle ilişkili transkripsiyonel değişiklikleri karakterize eder.