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JoVE Journal Medicine

用于研究NEC病理生理学的微流控坏死性小肠结肠炎芯片模型

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Journal (Medicine)

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Journal (Medicine)

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl₄) Exposure Through an Orogastric Tube

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用于研究NEC病理生理学的微流控坏死性小肠结肠炎芯片模型

A Necrotizing Enterocolitis Model for Mechanistic Studies and Drug Discovery

Article DOI: 10.3791/200450-v • 06:10 min • July 28th, 2023

July 28th, 2023 •

Lauren C. Frazer¹, Yukihiro Yamaguchi¹, Corey M. Jania¹, Wyatt E. Lanik², Qingqing Gong³, Dhirendra K. Singh¹, Stephen Mackay¹, Natalia S. Akopyants¹, Misty Good¹

¹Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, ²University of Nebraska College of Medicine, ³Department of Surgery, Washington University School of Medicine

Tags

微流控模型，坏死性小肠结肠炎，人新生儿肠道类肿瘤，菌群失调微生物组，复杂发病机制，肠紧密连接，肠道屏障通透性，上皮细胞死亡，微生物菌群失调，炎症失调，动物模型，细胞系，肠道类器官，体外模型，微流控技术， NEC-on-a-chip，早产儿，人内皮细胞，药物发现测试

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