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CYP2D6 Animal Model
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CYP2D6 Animal Model: Hvordan å indusere autoimmun hepatitt i Mus

Article DOI: 10.3791/3644-v • 09:03 min • February 3rd, 2012
February 3rd, 2012 •
1, 1, 1
1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt

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Infeksjon av mus med en Adenovirus uttrykker humane autoantigen cytokrom P450 2D6 (hCYP2D6) anerkjent av sera av pasienter som lider av type 2 autoimmun hepatitt resultater i en vedvarende form for autoimmun-mediert leversykdom preget av omfattende hepatitt, fibrose og generering av en CYP2D6 -spesifikk immunrespons.

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Medisin autoimmunitet lever autoantigen fibrose perfusjons
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