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JoVE Journal Immunology and Infection
Utilizando o rato como um BLT humanizado baseado Stem Modelo Gene Therapy célula tumoral
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Utilizando o rato como um BLT humanizado baseado Stem Modelo Gene Therapy célula tumoral

Article DOI: 10.3791/4181-v • 06:59 min • December 18th, 2012
December 18th, 2012 •
1,2,3, 1,2, 1,2, 1,2, 4, 4, 1,2,3, 1,2,5
1Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology, David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA

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A geração e caracterização de células T específicas de tumor utilizando ratinhos humanizados é descrita aqui. Tecido do timo humano e geneticamente modificadas de células-tronco hematopoiéticas são transplantadas em ratos imunocomprometidos. Isto resulta na reconstituição de um sistema imune humano permitindo engenharia para exame in vivo de anticorpos anti-tumorais respostas imunes.

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Biologia do Câncer Edição 70 Stem Cell Biology Imunologia Engenharia Biomédica Medicina Bioengenharia Genética Oncologia ratos humanizados o transplante de células-tronco células-tronco, as células T o cancro modelo animal
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