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JoVE Journal
Genetics

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Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells
 

Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells

Article doi: 10.3791/57140
June 1st, 2018

Summary June 1st, 2018

This is a method to identify novel DNA-interacting proteins at specific target loci, relying on sequence-specific capture of crosslinked chromatin for subsequent proteomic analyses. No prior knowledge about potential binding proteins, nor cell modifications are required. Initially developed for yeast, the technology has now been adapted for mammalian cells.

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