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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

English

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8,937 Views

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08:39 min

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September 07, 2018

DOI:

10.3791/57981-v

DOI:
10.3791/57981-v

•

08:39 min
September 07, 2018

•

5 Views
, , , , , , , , , , , , ,
1Department of Neurological Surgery,Ohio State University, 2Department of Surgery,Ohio State University, 3Department of Surgery,Duke University, 4Department of Internal Medicine,Ohio State University

Summary

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Here, we present the modifications necessary to a well characterized and commonly used small animal ferric chloride-induced (FeCl3) carotid artery injury model for use in a large animal vascular injury model. The resulting model can be utilized for pre-clinical trial assessment of both prophylactic and thrombolytic pharmacological and mechanical interventions.

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Huttinger, A. L., Wheeler, D. G., Gnyawali, S., Dornbos III, D., Layzer, J. M., Venetos, N., Talentino, S., Musgrave, N. J., Jones, C., Bratton, C., Joseph, M. E., Sen, C., Sullenger, B. A., Nimjee, S. M. Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury. J. Vis. Exp. (139), e57981, doi:10.3791/57981 (2018).

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