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氯化铁诱导的犬颈动脉血栓形成: 一种大的血管损伤动物模型

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Medicine

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JoVE Journal Medicine

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

Please note that all translations are automatically generated. Click here for the English version.

氯化铁诱导的犬颈动脉血栓形成: 一种大的血管损伤动物模型

DOI:

10.3791/57981-v

•

08:39 min

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September 07, 2018

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Allyson L. Huttinger, Debra G. Wheeler, Surya Gnyawali, David Dornbos III, Juliana M. Layzer, Nicholas Venetos, Spencer Talentino, Nicholas J. Musgrave, Cheyenne Jones, Camille Bratton, Matthew E. Joseph, Chandan Sen, Bruce A. Sullenger, Shahid M. Nimjee

¹Department of Neurological Surgery,Ohio State University, ²Department of Surgery,Ohio State University, ³Department of Surgery,Duke University, ⁴Department of Internal Medicine,Ohio State University

Chapters

00:04Title
00:51Canine Angiography
04:06Canine Carotid Artery Occlusion
06:19Results: Representative Carotid Blood Flow and Post Occlusion Imaging
07:34Conclusion

Summary

Automatic Translation

在此, 我们提出了必要的修改, 以良好的特点和常用的小动物氯化铁诱导 (FeCl₃) 颈动脉损伤模型, 用于大动物血管损伤模型。结果模型可用于临床前试验评估预防和溶栓的药理和机械干预。

Tags

Ferric Chloride-induced Canine Carotid Artery Thrombosis Large Animal Model Vascular Injury Thrombosis Physiological Parameters Complete Blood Count Platelet Function Angiography Histology Serial Blood Sampling Carotid Artery Occlusive Thrombus Femoral Artery Guide Wire Angiographic Catheter Contrast Injection Blood Pressure Measurements

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