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Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
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JoVE Journal Behavior
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

DOI:
10.3791/58150-v

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03:46 min

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October 11, 2018

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, ,
1Section on Neuroadaptation and Protein Metabolism, National Institute of Mental Health,National Institutes of Health

Chapters

  • 00:04Title
  • 00:32Experimental Setup
  • 01:22Sleep Deprivation
  • 02:37Results: Chronic Sleep Restriction Alters Social Behavior
  • 03:12Conclusion

Summary

Automatic Translation

Automatic Translation

We describe a sleep deprivation technique known as gentle handling where investigators gently prod mice any time sleep behavior is observed. This method is a powerful tool that allows researchers to study the effects that chronic sleep restriction throughout development can have on future brain physiology and behavior.

Tags

Keywords: Chronic Sleep DeprivationMouse PupsGentle HandlingPostnatal DevelopmentSleep RestrictionSleep Deprivation ProtocolControl GroupSleep MonitoringSociability TestSocial NoveltyRecovery Period

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