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JoVE Journal Developmental Biology
Realización de Xenoinjertos musculares esqueléticos humanos en ratones inmunodeficientes
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Realización de Xenoinjertos musculares esqueléticos humanos en ratones inmunodeficientes

Article DOI: 10.3791/59966-v • 07:48 min • September 16th, 2019
September 16th, 2019 •
1,2, 2,3, 1,2,3,4, 1,2,4
1Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2Department of Neurology, Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience, Johns Hopkins University School of Medicine

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Las enfermedades humanas complejas pueden ser difíciles de modelar en los sistemas de modelos de laboratorio tradicionales. Aquí, describimos un enfoque quirúrgico para modelar la enfermedad muscular humana a través del trasplante de biopsias musculares esqueléticas humanas en ratones inmunodeficientes.

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Biología del desarrollo número 151 xenoinjerto músculo esquelético trasplante modelo NOD-Rag1nulidadIL2r -ratones nulos, inmunocomprometidos miositis enfermedad muscular
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