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DOI: 10.3791/60336-v
This article presents a novel automated experimental system designed to assess social behavior in small rodent models. The system provides multiple behavioral parameters for a comprehensive analysis of social preference and novelty preference tests.
Described here is a novel automated experimental system that offers an alternative to the three-chamber test and also solves several caveats. This system supplies multiple behavioral parameters that enable rigorous analysis of small rodent behavioral dynamics during the social preference and social novelty preference tests.
Exploring the neurobiological mechanisms of social behavior requires behavioral tests that can be applied to animal models in an unbiased and observer independent manner. Our system allows a detailed investigation of social behaviors and their their dynamics in small rodent models and supports accurate comparisons between strains, conditions and treatments. This system may be used for any type of social discrimination tests, such as discriminating between males and females.
Moreover, there are no limits to the sizes of the subjects. The analysis requires some experience for selecting the optimal parameters for tracking. For new users I recommend monitoring the tracking on the computer screen for the initial evaluation.
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