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JoVE Journal Medicine
A Whole Body Dosimetrie Protocol for Peptide-Receptor Radionuclide Therapy (PRRT)
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A Whole Body Dosimetrie Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Article DOI: 10.3791/60477-v • 09:49 min • April 24th, 2020
April 24th, 2020 •
1, 1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 4, 5, 3, 1
1Medical Physics Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 2Oncology Pharmacy, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 3Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 4Radiation Research Unit, Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy, 5Medical Physics Unit, Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy

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Diese Methode schätzt die absorbierte Dosis verschiedener Strukturen für die Peptid-Rezeptor-Radionuklid-Therapie (PRRT) mit der Möglichkeit, Organüberlappungen bei 2D-Projektionen zu vermeiden. Serielle ganzkörperplanare Bilder ermöglichen die Abschätzung der mittleren absorbierten Dosen entlang des ganzen Körpers, während der hybride Ansatz, der planare Bilder und 3D-SPECT/CT-Bild kombiniert, die Grenzen der Überlappung von Strukturen überwindet.

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Medizin Ausgabe 158 Dosimetrie ganzkörperige planare Bildgebung Hybriddosimetrie Theragnostik PSMA Protektoren SPECT
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