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Journal / Medicine / In vivo-musmodell av ryggradsimplantatinfektion
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In vivo-musmodell av ryggradsimplantatinfektion

Article DOI: 10.3791/60560-v • 08:03 min • June 23rd, 2020
June 23rd, 2020 •
1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 3, 2, 2, 2, 2, 2, 1, 1, 1
1Department of Orthopaedic Surgery, University of California Los Angeles, 2David Geffen School of Medicine, University of California Los Angeles, 3University of South Carolina School of Medicine, University of South Carolina

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Protokollet beskriver en ny in vivo-musmodell av ryggradsimplantatinfektion där ett k-trådimplantat av rostfritt stål infekteras med bioluminescerande Staphylococcus aureus Xen36. Bakteriebördan övervakas longitudinellt med bioluminescerande avbildning och bekräftas med antal kolonibildande enheter efter avlivning.

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Ryggradsimplantatinfektion musmodell in vivo terapier behandlingsstrategier ryggradskirurgi bioluminescerande stam Staphylococcus aureus Xen36-bakterier bioluminiscensavbildning bakteriell börda periimplantatvävnad kolonibildande enheter (CFU) djurmodeller
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