/
/
Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:04Introduction
- 00:46Cartilage Cationic Peptide Carrier (CPC) Equilibrium Uptake
- 02:20CPC Cartilage Depth of Penetration Analysis
- 04:36Non-Equilibrium CPC Cartilage Diffusion Rate
- 06:23Results: Representative Cartilage Depth of Penetration and Non-Equilibrium Diffusion Analyses
- 08:20Conclusion
This protocol determines equilibrium uptake, depth of penetration and non-equilibrium diffusion rate for cationic peptide carriers in cartilage. Characterization of transport properties is critical for ensuring an effective biological response. These methods can be applied for designing an optimally charged drug carriers for targeting negatively charged tissues.
