This protocol describes the implantation of human coronary stents into the abdominal aorta of rats with an apoE-/- background using a trans-femoral access. Compared with other animal models, murine models carry the advantages of high throughput, reproducibility, ease of handling and housing, and a broad availability of molecular markers.
Cornelissen, A., Florescu, R., Schaaps, N., Afify, M., Simsekyilmaz, S., Liehn, E., Vogt, F. Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access. J. Vis. Exp. (165), e61442, doi:10.3791/61442 (2020).