Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Anne Cornelissen; Roberta Florescu; Nicole Schaaps; Mamdouh Afify; Sakine Simsekyilmaz; Elisa Liehn; Felix Vogt

doi:10.3791/61442

Journal

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Medicine

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Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

JoVE Journal
Medicine

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JoVE Journal Medicine

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

4,227 Views

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05:04 min

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November 19, 2020

DOI:

10.3791/61442-v

DOI:

10.3791/61442-v

•

05:04 min

November 19, 2020

•

4193 Views

Anne Cornelissen*¹, Roberta Florescu*¹, Nicole Schaaps¹, Mamdouh Afify¹, Sakine Simsekyilmaz¹, Elisa Liehn*^1,2,3, Felix Vogt*¹

¹Division of Cardiology, Angiology, and Critical Care,University Hospital RWTH Aachen ²Department for Operative Intensive Medicine,University Hospital RWTH Aachen ³Institute for Pathology “Victor Babes”

Summary

This protocol describes the implantation of human coronary stents into the abdominal aorta of rats with an apoE^-/- background using a trans-femoral access. Compared with other animal models, murine models carry the advantages of high throughput, reproducibility, ease of handling and housing, and a broad availability of molecular markers.