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Identifizierung von EGFR- und RAS-Inhibitoren mittels Caenorhabditis elegans
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Identifizierung von EGFR- und RAS-Inhibitoren mittels Caenorhabditis elegans

Article DOI: 10.3791/61788-v • 08:12 min • October 5th, 2020
October 5th, 2020 •
1,2, 1, 1, 1, 2, 1
1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center

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Der genetisch traktierbare Fadenwurm Caenorhabditis elegans kann als einfaches und kostengünstiges Modell für die Wirkstoffforschung verwendet werden. Hier wird ein Protokoll zur Identifizierung von Krebsmedikamenten beschrieben, die die nachgeschaltete Signalübertragung von RAS- und EGFR-Proteinen hemmen.

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Krebsforschung Ausgabe 164 Caenorhabditis elegans LET-60 LET-23 K-RAS EGFR GFP
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