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Continue fluorescentie-gebaseerde endonuclease-gekoppelde DNA-methylatietest om te screenen op DNA-methyltransferaseremmers
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Continue fluorescentie-gebaseerde endonuclease-gekoppelde DNA-methylatietest om te screenen op DNA-methyltransferaseremmers

Article DOI: 10.3791/62949-v • 06:07 min • August 5th, 2022
August 5th, 2022 •
1, 2, 2
1Department of Chemistry, Bucknell University, 2Program in Cell Biology/Biochemistry, Bucknell University

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DNA-methyltransferasen zijn potentiële doelwitten van kankergeneesmiddelen. Hier wordt een protocol gepresenteerd om kleine moleculen te beoordelen op DNA-methyltransferaseremming. Deze test maakt gebruik van een endonuclease om DNA-methylatie te koppelen aan fluorescentiegeneratie en maakt het mogelijk om enzymactiviteit in realtime te volgen.

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Biochemie Nummer 186 Biochemie Kwestie ,
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