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A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
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Neuroscience
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JoVE Journal Neuroscience
A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid

DOI:
10.3791/63005-v

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06:22 min

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September 03, 2021

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, , , , , ,
1Department of Rehabilitation Medicine, West China Hospital,Sichuan University, 2Department of Rehabilitation Medicine, Daping Hospital,Army Medical University, 3Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital,Sichuan University, 4Department of physiology,Southwest Medical University, 5Department of Rehabilitation Sciences,The Hong Kong Polytechnic University, 6Laboratory of Nonhuman Primate Disease Modeling Research, State Key Laboratory of Biotherapy, West China Hospital,Sichuan University, 7Sichuan Kangcheng Biotech Co., Inc.

Chapters

  • 00:04Introduction
  • 00:50Serial Cisterna Magna Cerebrospinal Fluid (CSF) Sampling Method
  • 02:34Monkey Chair Adaptive Training
  • 03:07rTMS Adaptive Training/Sham Stimulation
  • 03:39Treatment Protocol
  • 04:07CSF Biomarkers, CSF Collection, and Index Detection Method
  • 04:40Results: Effect of rTMS Stimulation with Different Frequencies on Aβ and Tau Metabolism
  • 05:57Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we describe the procedure for a pilot study to explore the effect of repetitive transcranial magnetic stimulation with different frequencies (1 Hz/20 Hz/40 Hz) on Aβ and tau metabolism in rhesus monkey cerebrospinal fluid.

Tags

Keyword Extraction: Repetitive Transcranial Magnetic StimulationAlpha-betaTauRhesus MonkeyCerebrospinal FluidCisterna MagnaCSF SamplingAnesthesiaSpinal NeedleEpidural CatheterSubarachnoid SpaceSampling PortBiomarker AnalysisRTMS Intervention

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