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JoVE Journal Bioengineering
Criação de uma articulação do joelho em um chip para modelagem de doenças articulares e testes de medicamentos
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Criação de uma articulação do joelho em um chip para modelagem de doenças articulares e testes de medicamentos

Article DOI: 10.3791/64186-v • 12:44 min • January 27th, 2023
January 27th, 2023 •
1,2, 1,3, 1, 1, 1, 1, 1, 1, 4, 5, 4,6, 1,8, 1,7, 1,2,7
1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 2Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, 3Department of Neurobiology, University of Pittsburgh School of Medicine, 4Department of Orthopaedic Surgery, Stanford University, 5Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 6Department of Bioengineering, Stanford University, 7McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, 8The Chinese University of Hong Kong

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Fornecemos métodos detalhados para gerar quatro tipos de tecidos a partir de células-tronco mesenquimais humanas, que são usadas para recapitular a cartilagem, osso, coxim gorduroso e sinóvia na articulação do joelho humano. Esses quatro tecidos são integrados em um biorreator personalizado e conectados através de microfluídica, gerando assim uma articulação do joelho em um chip.

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Bioengenharia osteoartrite chip de tecido drogas modificadoras de doenças para osteoartrite sistema microfisiológico
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