Our research aims to identify gender-specific genes in glial cells, explore associated pathways, and evaluate the potential therapeutic effects of TCM on Alzheimer’s disease. The present protocol analyzes a large number of single-nuclei transcriptomes from the GEO database through bioinformatics analysis. Our protocol offers advantages, including single-cell resolution, CTAP identification of biomarker discovery, and comparison of growth in different genders.
Our laboratory will focus on the field of neuroscience with a parameter focus on utilizing acupuncture to enhance the treatment of neurological disorders.
Liu, H., Yang, H., Liu, S., Li, S., Yang, W., Ayesha, A., Tan, X., Jiang, C., Liu, Y., Xie, L. Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles. J. Vis. Exp. (207), e66552, doi:10.3791/66552 (2024).