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Modelo Spinotrapezius murino para avaliar o impacto da ligadura arteriolar em função microvascular e Remodelação
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Modelo Spinotrapezius murino para avaliar o impacto da ligadura arteriolar em função microvascular e Remodelação

Article DOI: 10.3791/50218-v • 16:43 min • March 3rd, 2013
March 3rd, 2013 •
*1, *1, 2, 3, 1, 4, 2, 1
1Department of Biomedical Engineering, University of Virginia, 2Department of Biomedical Engineering, California Polytechnic State University, 3Office of Animal Welfare, University of Virginia, 4Department of Biomedical Engineering & Institute for Computational Medicine, Johns Hopkins University
* These authors contributed equally

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Nós demonstramos um modelo de ligadura arterial novel no músculo spinotrapezius murino, incluindo um procedimento passo-a-passo e uma descrição da instrumentação necessária. Descrevemos a cirurgia e avaliação dos resultados relevantes referentes à remodelação da rede vascular e vasodilatação funcional usando microscopia intravital e confocal.

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Engenharia Biomédica Edição 73 Medicina Anatomia Fisiologia Cirurgia Imunologia Hematologia microvasos capilares arteríolas vênulas doenças vasculares isquemia spinotrapezius doença vascular periférica vasodilatação funcional ligadura arteriolar vasos circulação microscopia confocal modelo animal
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