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JoVE Journal Bioengineering
One Minute, Sub-One-Watt Photothermal Tumor Fjernelse Brug Porphysomes, Intrinsic Multifunktionel Nanovesicles
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One Minute, Sub-One-Watt Photothermal Tumor Fjernelse Brug Porphysomes, Intrinsic Multifunktionel Nanovesicles

Article DOI: 10.3791/50536-v • 09:51 min • September 17th, 2013
September 17th, 2013 •
1,2,3, 4, 1,2,3
1Department of Pharmaceutical Sciences, University of Toronto, 2The Institute of Biomaterials and Biomedical Engineering, University of Toronto, 3Ontario Cancer Institute, Campbell Family Institute For Cancer Research and Techna Institute, 4Department of Biomedical Engineering, University at Buffalo, The State University of New York

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Vi udviklede nye iboende multifunktionelle nanovesicles kaldet porphysomes, som har struktur-afhængige fluorescens selv-quenching og unikke photothermal egenskaber og fungerer dermed som potente photothermal terapi agenter. Vi formulerede porphysomes hjælp højtryk ekstrudering og undersøgte deres photothermal terapi effekt i en xenograft tumor model.

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Bioteknik Nanopartikler Porphysome photothermal terapi nanopartikel porfyrin
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