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Bioluminescenza Imaging di Neuroinflammation in topi transgenici Dopo periferica inoculazione di alfa-sinucleina fibrille

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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Iniezione periferica di fibrille alfasinucleina nel peritoneo o linguetta di Tg (M83 +/-: GFAP -Luc +/-) topi che esprimono umana alfasinucleina con la mutazione A53T familiare e luciferasi di lucciola, può indurre neuropatologia, compreso neuroinflammation , nel loro sistema nervoso centrale.

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Neuroscienze Numero 122 Alpha-sinucleina l'imaging bioluminescenza infiammazione synucleinopathy neuroinvasione il morbo di Parkinson periferiche prioni-like prionoid
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