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Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
JoVE Journal
Medicine
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JoVE Journal Medicine
Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
DOI:

08:39 min

September 07, 2018

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Chapters

  • 00:04Title
  • 00:51Canine Angiography
  • 04:06Canine Carotid Artery Occlusion
  • 06:19Results: Representative Carotid Blood Flow and Post Occlusion Imaging
  • 07:34Conclusion

Summary

Automatic Translation

Here, we present the modifications necessary to a well characterized and commonly used small animal ferric chloride-induced (FeCl3) carotid artery injury model for use in a large animal vascular injury model. The resulting model can be utilized for pre-clinical trial assessment of both prophylactic and thrombolytic pharmacological and mechanical interventions.

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